Bases moleculares de la interacción esticolisina-membrana sobre la estructura del poro y los efectos de los lípidos

Abstract

The usefulness of toxicity across the tree of life is far beyond doubt. Most, if not all, organisms produce compounds that can be used for attack and/or defense against external entities. Some of the most specialized of these compounds are toxic proteins, among which pore-forming toxins (PFTs) particularly excel. PFTs are present in all kingdoms of life. Given the wide variety of PFTs, one can expect a multitude of different specificities and mechanisms of action, of which we will certainly take advantage at some point. For that, a thorough characterization of PFTs and their functionality is necessary. In this thesis, we have taken further the characterization of sticholysins, small PFTs produced by the sea anemone Stichodactyla helianthus...