Hybrid nanosystems for the delivery of therapeutic agents as treatment for complex diseases

  1. Moreno Zafra, Victor Manuel
Dirixida por:
  1. Alejandro Baeza García Director
  2. María Vallet-Regí Director

Universidade de defensa: Universidad Complutense de Madrid

Fecha de defensa: 05 de xullo de 2021

Tribunal:
  1. Montserrat Colilla Nieto Presidenta
  2. Isabel Izquierdo Barba Secretario/a
  3. Juana Serrano López Vogal
  4. Daniel Ruiz Molina Vogal
  5. Jesús Martínez de la Fuente Vogal
Departamento:
  1. Química en Ciencias Farmacéuticas

Tipo: Tese

Resumo

The overall objective of this doctoral thesis has been the design of various nanomaterials with the aim of addressing distinct approaches to treat cancer and fibrosis, as well as overcoming some of the biological barriers that restrict nanomedicine-based therapies.These biological restrictions entail important limitations in the fight against cancer based on nanomedicines. Some of them are the sequestration of nanoparticles by the mononuclear phagocytic system, the lack of selectivity of conventional chemotherapy, which generates undesirable side-effects and disfunctions in organs or tissues, or the scarce penetration of nanoparticles within the target diseased tissue. Recent interest in the design of nanosystems that overcome these constraints is generating new tools for the effective treatment of cancer, as well as other pathologies...