Estudio morfológico de la neurocarcinogénesis experimental inducida por nitroso-ureas

  1. Zurita, Mercedes
  2. Vaquero Crespo, Jesús
  3. Oya Otero, Santiago de
  4. Bonilla, Celia
  5. Aguayo, C.
Revista:
Anales de la Real Academia Nacional de Farmacia

ISSN: 1697-4298 0034-0618

Año de publicación: 2008

Número: 2

Páginas: 257-282

Tipo: Artículo

Otras publicaciones en: Anales de la Real Academia Nacional de Farmacia

Resumen

This work shows a revision of the chemical neurocarcinogenesis, with special reference to the Nervous System tumors induced by ethyl-nitrosourea in the Wistar rat. Prenatal administration of this carcinogen (50 mg/kg, day 17 of pregnancy) induces Nervous System tumors with histological features of malignant schwannomas or oligodendrogliomas. However, and independently of their morphology, the immunohistochemical and ultrastructural studies allow to classify to these tumors as undifferentiated malignant tumors, with tumor cells showing possible differentiation toward neuronal and glial phenotypes. Their biologic properties and their possible diagnosis in vivo, by means of Magnetic Resonance, make this neurocarcinogenesis model to be extraordinarily useful to value the effect of new drug treatments, applicable to human malignant brain tumors