Identificación de biomarcadores plasmáticos asociados a la infección por SARS-CoV-2 en personas con VIH

  1. CRESPO BERMEJO, CELIA
Supervised by:
  1. Verónica Briz Director
  2. Amanda Fernández Rodríguez Director
  3. Ricardo Madrid González Director

Defence university: Universidad Complutense de Madrid

Defense date: 10 July 2024

Committee:
  1. Laura Benítez Rico Chair
  2. Nuria Muñoz Rivas Secretary
  3. Marta Garcia Contreras Committee member
  4. Juan Carlos Ambrosioni Czyrko Committee member
  5. María Eulalia Valencia Ortega Committee member
Faculty: Ciencias Biológicas
Universidad: Complutense University of Madrid

Type: Thesis

Teseo: O855659 DIALNET HANDLE: https://hdl.handle.net/20.500.14352/108467
Docta Complutense: lock_openOpen access Handle

Abstract

The COVID-19 pandemic, caused by SARS-CoV-2, has raised specific concerns for people with HIV (PHIV). Both infections are associated with issues related to chronic inflammation, premature aging, the risk of developing cancer, and cardiovascular disease (CVD), and they affect microRNA (miRNA) expression levels. The main objective of this thesis was to analyze the mid-term impact of SARS-CoV-2 infection on PHIV, through the determination of plasma biomarkers related to the aspects described above and the analysis of miRNA profiles.A total of 95 PHIV on antiretroviral therapy were included, stratified according to their SARS-CoV-2 infection status: 1) 48 PHIV at ≥ 12 weeks since SARS-CoV-2 infection diagnosis (PCR+) (HIV/SARS) and 2) 47 PHIV without prior SARS-CoV-2 infection (HIV). Epidemiological and clinical data were collected from medical records. Plasma markers associated with chronic inflammation, premature aging, cancer risk and CVD were selected and quantified using Procartaplex multiplex ELISA assays (InvitrogenTM, Thermo Fisher Scientific, USA)...