RAFAEL
LEÓN MARTÍNEZ
Profesor asociado
Instituto de Investigaciones Biomédicas Alberto Sols
Madrid, EspañaPublicacions en col·laboració amb investigadors/es de Instituto de Investigaciones Biomédicas Alberto Sols (6)
2024
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Discovery of a potent melatonin-based inhibitor of quinone reductase-2 with neuroprotective and neurogenic properties
European Journal of Medicinal Chemistry, Vol. 277
2022
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Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades
Journal of Medicinal Chemistry, Vol. 65, Núm. 6, pp. 4727-4751
2020
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Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties
European Journal of Medicinal Chemistry, Vol. 190
2019
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The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation
Aging Cell, Vol. 18, Núm. 3
2018
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The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca 2+ dysregulation, and mitochondrial abnormalities
Journal of Neurochemistry, Vol. 145, Núm. 2, pp. 170-182
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Transcription factor NRF2 as a therapeutic target for chronic diseases: A systems medicine approach
Pharmacological Reviews, Vol. 70, Núm. 2, pp. 348-383