Publicaciones en colaboración con investigadores/as de GlaxoSmithKline (Spain) (55)

2021

  1. A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides

    British Journal of Pharmacology, Vol. 178, Núm. 2, pp. 363-377

  2. The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957

    Scientific Reports, Vol. 11, Núm. 1

2020

  1. Identification of Selective Inhibitors of Plasmodium N-Myristoyltransferase by High-Throughput Screening

    Journal of Medicinal Chemistry, Vol. 63, Núm. 2, pp. 591-600

2018

  1. A high throughput screen for next-generation leads targeting malaria parasite transmission

    Nature Communications, Vol. 9, Núm. 1

  2. Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria" (Antimicrobial Agents and Chemotherapy (2018) 62:9 (e00012-18) DOI: 10.1128/AAC.00012-18)

    Antimicrobial Agents and Chemotherapy

  3. Gametocytes from K13 propeller mutant plasmodium falciparum clinical isolates demonstrate reduced susceptibility to dihydroartemisinin in the male gamete exflagellation inhibition assay

    Antimicrobial Agents and Chemotherapy, Vol. 62, Núm. 12

  4. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

    Science, Vol. 359, Núm. 6372, pp. 191-199

  5. Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials

    Journal of Antimicrobial Chemotherapy, Vol. 73, Núm. 5, pp. 1279-1290

  6. Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones

    Journal of Medicinal Chemistry, Vol. 61, Núm. 8, pp. 3422-3435

  7. Uct943, a next-generation plasmodium falciparum pi4k inhibitor preclinical candidate for the treatment of malaria

    Antimicrobial Agents and Chemotherapy, Vol. 62, Núm. 9

2017

  1. A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

    Nature Communications, Vol. 8

  2. Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

    Nature Communications, Vol. 8

2016

  1. A broad analysis of resistance development in the malaria parasite

    Nature Communications, Vol. 7

  2. A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents

    Malaria Journal, Vol. 15, Núm. 1

  3. Transmission-blocking potential of MEFAS, a hybrid compound derived from artesunate and mefloquine

    Antimicrobial Agents and Chemotherapy, Vol. 60, Núm. 5, pp. 3145-3147

2015

  1. A new Set of chemical starting points with Plasmodium falciparum transmission-blocking potential for antimalarial drug discovery

    PLoS ONE, Vol. 10, Núm. 8

  2. Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

    Malaria Journal, Vol. 14, Núm. 1

  3. Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation

    Antimicrobial Agents and Chemotherapy, Vol. 59, Núm. 6, pp. 3298-3305

2013

  1. Estandarización de un modelo murino de malaria cerebral en fases clínicas para la evaluación de terapias antimaláricas y de rescate

    Anales de la Real Academia Nacional de Farmacia, Vol. 79, Núm. 2, pp. 274-292

  2. Glutathione peroxidase contributes with heme oxygenase-1 to redox balance in mouse brain during the course of cerebral malaria

    Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1832, Núm. 12, pp. 2009-2018