Aspectos comparativos entre el cáncer mamario humano y canino con especial referencia al cáncer mamario inflamatoriogrado histológico de malignidad, mecanismos endocrinos e interleucinas

Abstract

Nowadays human breast cancer (HBC) is one of the biggest health problems for women worldwide. Breast cancer is the most frequently diagnosed cancer in women and the second leading cause of death from cancer. Inflammatory breast cancer in women and in female dogs is a particularly aggressive type of breast/mammary cancer with low incidence. Canine inflammatory mammary cancer (IMC) has been proposed as the best natural model to study inflammatory breast cancer. This type of breast cancer is considered a clinical entity in itself, characterized by edema, redness and pain that usually affect the entire breast. It appears very often without a nodule, which makes the diagnosis very difficult, and often mistaken for dermatitis or mastitis. On the other hand, canine mammary cancer (CMC) is presented as the most diagnosed cancer in female dogs, accounting for 52% of all malignancies and the second most common after skin tumors in both sexes. In the canine species IMC represents 7.6% of all canine mammary tumors and 17% of all malignant mammary neoplasms. A great deal of knowledge about breast cancer is based on research conducted in vitro or in vivo. On numerous occasions, spontaneous canine mammary tumors have been proposed as a model for the study of HBC. It has been shown that the canine species is a good model for researching IBC in women because of the very similar epidemiologic, clinical and histological features between the two species. However, most comparable aspects in breast cancers of both species, including the hormonal profile or the presence of certain cytokines, have not yet been evaluated ...