Estudio cronobiológico de la respuesta farmacológica y la variación de parámetros hemodinámicos de la combinación etomidato-Midazolam en perros y gatos

Abstract

A fundamental doctrine of biology, medicine, physiology and pharmacology is the relative constancy of the internal biological environment (Homeostasis). Homeostatic variables are not maintained at a constant level, but within a certain interval repeated at regular intervals (Biological Rhythms) values; when the course is accomplished in a period of 24 h is called Circadian Rhythm. Synchronizers that define this rate are, among others, the light and darkness or sleep routine (rest-activity). Chronobiology studies the biological rhythms and timing mechanisms, determining the influence they can have on living things. The chronopharmacology, studies the effects of drugs on circadian rhythm function (either by alterations in its kinetics: chronopharmacokinetics, or in its dynamics: chronopharmacodynamics), determining the decisive period for administration, for increased efficiency and/or decrease its adverse effects. These changes are particularly important in the most critical pharmacological groups such as anesthetics because there are differences in the ability of anesthesia that depend on the time of day when these drugs are administered. Etomidate is a not barbiturate fast-acting anesthetic agent, recommended for induction of anesthesia in animals with diseases that compromise hemodynamic stability, as it does not cause severe alterations in the cardiovascular system or the intracranial pressure. It acts facilitating GABA-mediated transmission, interacting with an allosteric site of the GABA – ionophore Cl- receptor...