Ligandos asociados a moléculas HLA de clase I en infecciones virales y trastornos autoinmunitarios
- Daniel López Rodríguez Director
Defence university: Universidad Complutense de Madrid
Fecha de defensa: 16 June 2017
- Eduardo Martínez Naves Chair
- Julián Gómez Gutiérrez Secretary
- Salvador Iborra Martín Committee member
- Alberto Paradela Elizalde Committee member
- Blas Carlos Vilches Ruiz Committee member
Type: Thesis
Abstract
CD8+ T cells identify and kill tumor and infected cells through the specificrecognition of intracellular protein-derived peptides bound to human class I majorhistocompatibility (HLA class I) molecules. HLA class I presentation of these peptideligands is key for the control of various viral infections, and it has also been involvedin autoimmune diseases like spondyloarthropathies (SpAs). In this context, theextraordinary polymorphism of HLA class I molecules determines the peptide ligandsthat can bind to the different subtypes, because just the ligands displaying theappropriate residues in the right positions, allowing the interaction with specificamino acids in the HLA molecule, can bind to each particular HLA class I subtype...