Efectos neurotóxicos del cadmio sobre las neuronas colinérgicas del prosencéfalo basal y su implicación en la inducción de alteraciones cognitivas

  1. FRIAS GONZALEZ, MARIANO DE
Supervised by:
  1. Javier del Pino Sans Director
  2. María José Anadón Baselga Director
  3. María Teresa Frejo Moya Director

Defence university: Universidad Complutense de Madrid

Fecha de defensa: 20 February 2018

Committee:
  1. Fernando Marco Martínez Chair
  2. Elena Labajo González Secretary
  3. Ana María Cameán Fernández Committee member
  4. Jimena García Lobo Committee member
  5. Miguel Ángel Ruiz Ibán Committee member
Department:
  1. Farmacología y Toxicología

Type: Thesis

Teseo: 146503 DIALNET lock_openDocta Complutense editor

Abstract

Cadmium (Cd) is a neurotoxic compound that produces cognitive dysfunctions, although themechanisms involved are unknown. The learning and memory processes are regulated by thecholinergic system of the basal forebrain, therefore blockade of cholinergic transmission ordeath of cholinergic neurons in this region could be related to the deterioration of cadmiuminducedmemory. In this sense, it has been described in other brain regions that cadmium blockscholinergic transmission through the reduction of choline acetyltransferase (ChAT) activity andin turn blocks muscarinic receptors which may, in addition to participating in cholinergictransmission, participate in the maintenance of neuronal viability, specifically the muscarinicM1receptor (M1R). It has also been reported to induce selective killing of cholinergic neuronsat the peripheral level...