Desarrollo de un modelo murino gestante de la infección por "Neospora caninum"

Abstract

Our study confirms that timing of infection during pregnancy determines foetal losses and transmission to the offspring. Furthermore, N. caninum infection at the three pregnancy periods had fatal consequences for pups born from infected dams, leading to a delay in the general development of neonates, clinical signs compatible with neosporosis and histopathological lesions. In addition, infection during gestation induces changes in the immune response at the materno-foetal interface, demonstrating its importance in the outcome of gestation. Finally, we propose that infection at midgestation (day 7) and its study during the post-natal period is a valuable tool for testing new chemotherapeutic agents and vaccines against congenital neosporosis, before its use on bovine, in order to reduce the high mortality and transmission rates observed. In addition, differences in...