Stochastic and statistical analyses for investigating protein folding kinetics

Resumen

Understanding how natural proteins fold spontaneously onto their specific, biologically functional three-dimensional structures is both a fascinating fundamental problem in modern biochemistry and a necessary step towards developing technologies for protein engineering and designing protein-base nanodevices. One of the limitations that scientists working in this área have encountered in the past, however, was, was the difficulty in connecting analytical theory to experimental results. For a long time experimentalists could nos use theory to interpret their results. Theoretical predictions, moreover, were not amenable to experimental testing. Such limitations have been progressively reduced by the combination of key theoretical concepts, improved simultions, new experiments and their detailed quantitative analysis with simple statistical mechanical models. (sacado del informe del Dr. Victor Muñoz Van Den Eynde)