Nutritional considerations on platelet fatty acids in Major Depression and Ischemic Cardiovascular Disease

Resumo

In our study we have evaluated the theme of the platelet fatty acid composition in subjects with a clinical diagnosis of Major Depression (MD), in subjects with a clinical diagnosis of Ischemic Heart Disease (IHD) and in control subjects. As far as we know, the platelet fatty acid composition has never been analyzed before, in MD. The results obtained with a Self Organizing Map (SOM) show the evidence of three fatty acids, Arachidonic Acid (AA), Linoleic Acid (LA), and Palmitic Acid (PA) in a peculiar position with respect to the biochemical characterization of MD and three fatty acids, Arachidonic Acid (AA), Linoleic Acid (LA) and Oleic Acid (OA) in a peculiar position with respect to the biochemical characterization of the IHD. Nutritional considerations are done about the possibility of a positive modification of the platelet fatty acids in both pathologies.