Liberación de óxido nítrico en arterias tumorales de pacientes con cáncer colorrectal

Résumé

INTRODUCTION. Nitric oxide is an endothelium-derived relaxing factor involved in tumour growth because it could regulate celular proliferation, tumour angiogenesis and tumor blood flow. So this relaxation of tumour arteries could enhance medical effects of oncological therapy because facilitates the delivery of anticancer drugs to tumor cells and stimulates oxygenation of tumor tissue increasing the response to radiotherapy. MATERIAL AND METHOD. To study whether release of nitric oxide is altered in tumooir arteries, mesenteric arteries suppying blood flow to colorectal tumor, mesenteric arteries far from said tumor were obtained from 19 patients undergoing colectomy and mesenteric arteries were also obtained from surgical patients with diveticulitis (n=4) or inflammatory bowel disease (n=3). Arteries were prepared for isometric tension recording in an organ bath and were precontrated with U46619. The relaxation produced by bradykinin was recorded in each of these arteries with and without the nitric oxide sinthase inhibitor L-NAME and cyclooxygenase inhibitor meclofenamate. RESULTS. Bradykinin produced a dose-dependent relaxation that was similar in all the three types of artery. This relaxation was reduced with L-NAME and was not modified with meclofenamate. CONCLUSION. Nitric oxide release is preservered in human arteries supplying blood flow to colorectal tumors. Vol. XIII nº:4 (154-158) 2010 LIBERACIÓN DE ÓXIDO NÍTRICO EN ARTERIAS TUMORALES DE PACIENTES CON CÁNCER COLORRECTAL NITRIC OXIDE RELEASE ON TUMOUR ARTERIES FROM PATIENTS WITH COLORECTAL CANCER Labalde Martinez M*, Ferrero Herrero E*, García Villalón AL**, Diéguez Castrillo G**, Alonso Justo I, Hidalgo Pascual M* * Servicio de Cirugía General y del Aparato Digestivo B. Hospital Universitario 12 de octubre . Madrid. ** Departamento de Fisiología. Facultad de Medicina. Universidad Autónoma de Madrid. España. PALABRAS CLAVE Óxido nítrico, cáncel colorrectal, arterias tumorales. KEY WORDS Nitric oxide, colorectal cancer, tumoral arteries. Correspondencia: MARÍA LABALDE MARTÍNEZ C/Canarias 38 3-G � 28045 MADRID marialm007@hotmail.com TRABAJOS ORIGINALES INTRODUCCIÓN