Posible papel protector de la melatonina frente a la toxicidad neuroendocrina inducida por cadmio
- Romero Martínez, Alejandro
- Cabaleiro Ocampo, María Teresa
- Caride Figueroa, Ana
- Lafuente Giménez, Anunciación
ISSN: 0212-7113
Année de publication: 2008
Volumen: 25
Número: 1-3
Pages: 3-11
Type: Article
D'autres publications dans: Revista de toxicología
Résumé
Cadmium is one of the most important toxic chemicals due to its increasing level in the environment as a result of industrial and agricultural practices. As an endocrine disruptor, cadmium modifies pituitary hormone release. Indirect effects of cadmium provoke generation of reactive oxygen species and reduce activities of proteins involved in antioxidant defenses. Melatonin is a well-known potent antioxidant, free radical scavenger and metal chelator synthesized in the pineal gland. Thus, antioxidative actions of this nature protect against lipid peroxidation and oxidative damage by radicals and their toxic products. This review collates evidence from many research laboratories who reported antioxidant effects of melatonin and this mechanism could counteract oxidative stress and lipid peroxidation induced by cadmium exposure.