Estudio de citoquinas y proteínas de choque térmico en pacientes polifracturados

  1. Alejandro Ortiz Espada
  2. Francisco Chana Rodríguez
  3. Manuel Luis Tisner Madrid
  4. Javier Vaquero
  5. María Concepción Guisasola Zulueta

ISSN: 1888-6116

Year of publication: 2009

Volume: 20

Issue: 4

Pages: 201-210

Type: Article

More publications in: Trauma


SCImago Journal Rank

  • Year 2009
  • SJR Journal Impact: 0.104
  • Best Quartile: Q4
  • Area: Orthopedics and Sports Medicine Quartile: Q4 Rank in area: 182/220


Objective: To evaluate the repercussion and behavior of the serum levels of proinflammatory factors in relation to the appearance of clinical-surgical complications in polytraumatized patients. Material y Methods: The study comprised 18 polytraumatized patients, 10 males and 8 females, with two or more bone fractures and an injury severity score (ISS) >16, and with a mean age of 42 years, in which traffic accidents were the main cause of injury (44%). The mean ISS was 26.83, with a new injury severity score (NISS) of 33.72. Demographic data were collected, together with information on the injuries produced, the surgical interventions, outcome, complications and sequelae. Blood tests were performed to record leukocyte count, fibrinogen, C-reactive protein, TNF·, interleukin 1�, interleukin 6, heat shock protein HSP70i and antiHSP70i antibodies. Results: The TNF· values showed an ascending tendency, with an increase in slope starting 48 hours after trauma. IL-1 in turn showed a maximum value on occasion of the first measurement immediately after injury, followed by a gradual decrease. IL-6 showed values above 500 pg/ml. Peak serum HSP70i elevation were recorded at first determination, followed by a decrease over the following 48 hours. Conclusions: The established proinflammatory factor response curves will serve as a basis for future studies to consolidate them as biomarkers applicable to polytraumatized patients