Immunisation of rabbits with house dust mite extract does not protect against infection by Graphidium strigosum
- Cuquerella Ayensa, Montserrat
- Fawzi, E. M.
- Paramio, R.
- Alunda Rodríguez, José María
ISSN: 0718-8730
Año de publicación: 2011
Volumen: 70
Número: 1
Páginas: 58-64
Tipo: Artículo
Otras publicaciones en: Revista Ibero-latinoamericana de parasitología
Resumen
The effect of prior immunisation of rabbits with house dust mite extract (DpSE) on the challenge with 750 L3 of Graphidium strigosum, and the effect of immunisation with DpSE on a chronic gastric infection of rabbits with G. strigosum were studied. Immunisation did not provoke any signifi cant variation in the haematological (packed cell volume, leukocyte and eosinophil counts) and parasitological (prepatency period, parasite egg output and parasite burden) parameters determined in the infected rabbits. However, immunisation with DpSE elicited a signifi cant increase in IgG levels against both DpSE and G. strigosum soluble extract (ASE Gs). Higher levels of circulating anti-ASE Gs antibodies in immunised rabbits with a chronic helminth infection could be related to the cross-reactivity between DpSE and ASE Gs (ELISA and Western blotting).