Influencia de cefazolina y vancomicina en la resistencia al desgaste del cemento óseo
- Pablo Sanz Ruiz
- E. Paz Jiménez
- Juan Carlos del Real Romero
- J. Abenojar Buendía
- Javier Vaquero
- Francisco Forriol Campos
ISSN: 1888-6116
Year of publication: 2012
Volume: 23
Issue: 1
Pages: 59-63
Type: Article
More publications in: Trauma
Abstract
Objective: To evaluate experimentally the impact of the mixture of two antibiotics, vancomycin, and cefazolin, on resistance to bone cement wear (PMMA). Material and Methods: Six study groups were defined according to antibiotic and dose, performing three samples per group, which were subjected to wearing of the surface using a tribometer according to the ASTM G99-05 standard. The friction coefficients were measured and volumetric wear of each of them was quantified. We obtained electron scanning microscope images of each sample to observe the presence of changes in the surface of the samples. Results: All groups had wear data below the maximum admitted for commercial use. No significant differences were shown in friction coefficient or volumetric wear, except in group 4 (2.5% vancomycin + 2.5% cefazolin), which showed greater wear versus group 3 (2.5% vancomycin) (p<0.05). We saw a tendency towards greater wear and lower homogeneity in groups with cefazolin in its composition. Conclusions: Current bone cements can withstand mixtures with high doses of antibiotics without altering their mechanical properties. In addition to the amount of antibiotic, the choice is decisive, as not all antibiotics equally affect the properties of PMMA.