Trombólisis con dosis bajas de factor activador de plasminógeno en niños
- Santiago Lozano, Mª J.
- López Herce Cid, Jesús
- Zarzoso, S.
- Sánchez, A.
- Mencía Bartolomé, S.
- Carrillo Herranz, A.
ISSN: 1695-4033, 1696-4608
Año de publicación: 2012
Volumen: 76
Número: 2
Páginas: 77-82
Tipo: Artículo
Otras publicaciones en: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )
Resumen
Objective To analyse the efficacy and side effects of low doses of tissue plasminogen activator for the treatment of acute arterial and/or venous thrombosis in children. Patients and methods Prospective observational clinical study. 18 children between 1 months and 11 years treated with low doses (0.01-0.06mg/kg/h) of continuous intravenous thrombolytic therapy with t-PA were studied. Results A total of 94% of patients improved with low doses t-PA (72% complete resolution of the thrombosis and 22% partial resolution). One patient suffered a severe haemorrhage secondary to t-Pa and had to stop the treatment. The incidence of severe side effects was low (5%) Conclusions Thrombolytic therapy with low doses of t-PA (0.01-0.05mg/kg/h) is effective in a high percentage of children with acute arterial and/or venous thrombosis and produces a relatively low frequency of side effects.