Hipertensión portaldesarrollo de una respuesta inflamatoria sistémica asociada a síndrome metabólico
- Heras Jiménez, Natalia de las
- Aller Reyero, María Angeles
- Revuelta López, Elena
- Baeza, Gema
- Cachofeiro Ramos, María Victoria
- Arias Pérez, Jaime
- Lahera Juliá, Vicente
ISSN: 0214-9168, 1578-1879
Datum der Publikation: 2012
Ausgabe: 24
Nummer: 3
Seiten: 157-166
Art: Artikel
Andere Publikationen in: Clínica e investigación en arteriosclerosis
Zusammenfassung
Portal hypertension (PH) is characterised by increase in portal venous pressure by obstruction of portal flow. As a consequence of PH, a collateral circulation is developed, which shifts an important part of portal flow to the systemic circulation. Furthermore, hepatic steatosis is another feature of PH in the rat, which is also, associated which different risk factors such as, obesity, diabetes, hypercholesterolemia and hypertrygliceridemia. Several mechanisms such as insulin resistance, cytokine production and oxidative stress participate in the development of this clinical pathology. An experimental model of pre-hepatic portal hypertension by triple partial portal vein ligation enables complications produced both short-term or acute and long-term or chronic outcome to be studied. Most of the splanchnic and systemic alterations produced in this experimental model are of an inflammatory nature, and for this reason the study of the physiological mechanisms involved are of great interest to the research of new anti-inflammatory therapies.