Modificación del comportamiento celular bajo el efecto de estatinas en células de pared arterial (II). Alteraciones estructurales del citoesqueleto
- Álvarez-Sala Walther, Luis Antonio
- Recarte García Andrade, Carlos
- Álvarez Novés, Granada
- Álvarez Rodríguez, Ysmael
- Salor Moral, Diana
- Millán Núñez-Cortés, Jesús
ISSN: 0214-9168, 1578-1879
Year of publication: 2012
Volume: 24
Issue: 4
Pages: 196-201
Type: Article
More publications in: Clínica e investigación en arteriosclerosis
Abstract
Some of the clinical effects of HMG-CoA-reductase inhibitors (statins) may not be strictly dependent on the decrease in cholesterols and LDL-cholesterol. These effects, which are not related to their lipid lowering properties, are known as pleiotropic effects. In previous studies it has been shown that the pleiotropic effects may have changes in cell behaviour, assessing cell mobility and adhesion as substrate. That, along with the changes in the cell proliferation rate as well as apoptosis, leads to thinking that structural changes may be behind these not strictly lipid effects. In the present study, an attempt has been made to evaluate the changes induced in the cytoskeleton when vascular wall cells are incubated with statins. Fibroblast and smooth muscle fibres, and simvastatin and cerivastatin have been used. Our results have been able to confirm that the statins induce changes in the actin structures of the cell by using stains with immunofluorescence as well as anti-actin antibodies. These changes could explain the cells changes that accompany the variations in cell behaviour.