Sarcoidosis simulando una histiocitosis no Langerhans, tratada con antagonistas del factor de necrosis tumoral a

  1. Petiti Martin, G. Hebe
  2. Castellanos González, María
  3. Sanz Bueno, J.
  4. Burgués Calderón, M.
  5. Villar Buill, M.
  6. Vanaclocha Sebastián, Francisco
  7. Rodríguez Peralto, José Luis
Revista:
Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )

ISSN: 1695-4033 1696-4608

Año de publicación: 2012

Volumen: 77

Número: 4

Páginas: 267-271

Tipo: Artículo

DOI: 10.1016/J.ANPEDI.2012.01.024 DIALNET GOOGLE SCHOLAR

Otras publicaciones en: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP )

Resumen

Abstract Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin. Generalised eruptive histiocytosis is a rare, benign, self-healing, non-Langerhans� cell histiocytosis (non-LCH). We report the case of an 8-year-old girl with sarcoidosis who was misdiagnosed as non-LCH. She was treated with oral corticosteroids, methotrexate and adalimumab, but there was insufficient control of ocular disease. The introduction of infliximab achieved a control of the uveitis and enabled the corticosteroid dose to be tapered.In some cases of sarcoidosis the lack of well-organised granuloma formation at the beginning of the disease, and the presence of prominent giant cells may suggest alternative diagnoses, such as non-LCH. Although the experience of tumour necrosis factor- antagonists use in children with sarcoidosis is limited, these drugs may be helpful for those patients experiencing a severe and refractory disease.