Papel del tejido adiposo blanco en las complicaciones vasculares asociadas a la obesidad

  1. Gómez Hernández, Almudena 123
  2. Perdomo, Liliana 123
  3. Escribano, Oscar 123
  4. Benito de las Heras, Manuel 123
  1. 1 CIBER de Diabetes y Enfermedades Metabólicas Relacionadas
  2. 2 Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad Complutense de Madrid
  3. 3 Instituto de Investigación Sanitaria del Hospital Clínico San Carlos de Madrid (IdISSC)
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Revista:
Clínica e investigación en arteriosclerosis

ISSN: 0214-9168,  1578-1879

Año de publicación: 2013

Volumen: 25

Número: 1

Páginas: 27-35

Tipo: Artículo

DOI: 10.1016/J.ARTERI.2012.11.003 PMID: 23522279 SCOPUS: 2-s2.0-84873992103 DIALNET GOOGLE SCHOLAR

Otras publicaciones en: Clínica e investigación en arteriosclerosis

Resumen

En esta revisión se valora la contribución del tejido adiposo blanco en las complicaciones vasculares asociadas a la obesidad. El tejido adiposo blanco es un órgano metabólicamente activo y secretor de distintas moléculas que tienen una acción endocrina, paracrina y autocrina. El aumento de peso producido en la obesidad genera un exceso de grasa, generalmente visceral, responsable de la puesta en marcha de vías de señalización que activan la producción de citoquinas y quimioquinas proinflamatorias. Tanto los adipocitos como los macrófagos y linfocitos infiltrados y las células endoteliales contribuyen a la situación crónica inflamatoria de bajo grado presente en la obesidad. Además, el aumento de adiposidad no solo activa la respuesta inflamatoria en el propio adipocito, sino también en el hepatocito. Finalmente, los mediadores proinflamatorios y proaterogénicos que son producidos por el tejido adiposo blanco y el hígado y asociados a las células inmunes generan una inflamación sistémica que produce resistencia a la insulina en tejidos periféricos, además de contribuir al inicio del proceso aterogénico.

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Fuente de los datos: Dialnet