Bases genéticas y moleculares del cáncer colorrectal
- Labalde Martínez, María
- Ferrero Herrero, E.
- Veguillas Redondo, Pilar
- Pinto González, S.
- Carlín Gatica, J.
- Labrador Verdú, F.J.
- García-Parreño Jofré, Jorge
ISSN: 1139-8264
Year of publication: 2013
Volume: 16
Issue: 1
Pages: 25-31
Type: Article
More publications in: Revista española de investigaciones quirúrgicas
Abstract
Colorectal cancer is the third most common cancer wordlwide. Relative CRC risk is defined by genetic and environmental factors contributing to carcinogenesis by epigenetic mechanisms. Though only a 25 % CRC has been determined to have a familiar agregation with an important genetic component, all cases of CRC including sporadic ones present genetic aberrations that initiate three distinct molecular pathways of carcinogenesis implicating in different tumoral behaviours. Investigations about genes and molecular pathways implicated in the development of CRC have clinic aplications due to it could contribute to determine prognosis, elaborate a genetic conseling in case of familiar agregation and design therapeutic strategies according with molecular characteristics of tumor. On the other hand, A stem cell located in colonic epithelium with an acumulation of genetic mutations could be the cell that initiates the origin of CRC. The design of stem cell-targeted drugs could enhance reponsiveness to traditional therapeutic strategies and reduce local recurrence and metastasis.