Implicación de la molécula de adhesión ALCAM en el daño cerebralmodelo de daño neuronal mediante la administración de MDMA/éxtasis en rata
- Elia Moreno Cubero
- Esther O'Shea
- A. Rubio Araiz
- E. Torres
- Agustín Urrutia de Diego
- A. Mayado
- María Isabel Colado Megía
- M. D. Gutiérrez López
ISSN: 1888-6116
Datum der Publikation: 2013
Ausgabe: 24
Nummer: 2
Seiten: 101-108
Art: Artikel
Andere Publikationen in: Trauma
Zusammenfassung
Objective: 1) Characterization of ALCAM adhesion molecule expression in cortical vessels of MDMA-treated rats. 2) Study of the effect of the anti-inflammatory compound ibuprofen on ALCAM expression and on the neu- rotoxicity produced by MDMA. Material and methods: Male Dark Agouti rats were given a neurotoxic dose of MDMA. Ibuprofen was given before and at various times after MDMA. Rectal temperature was monitored during the treatment and ALCAM expression in vessels from cerebral cortex was determined at 24 h. In neurotoxicity studies, cortical 5-HT tissue levels and 5-HT transporter density were measured. Results: ALCAM expression was increased 24 h after MDMA treatment (p<0.01). Co-treatment with ibuprofen attenuated the increase in ALCAM levels (p<0.01) and partially prevented cerebral injury, reducing MDMA-indu- ced 5-HT (p<0.0001) and 5-HT transporter (p<0.0001) loss. Ibuprofen produced a minor modification in the MDMA-induced hyperthermia. Conclusions: Our study demonstrates an effect of MDMA on ALCAM expression. Thus, anti-inflammatory compounds such as ibuprofen may result useful in brain protection by inhibiting the effects of ALCAM and reducing brain damage although the potential contribution of the attenuation of MDMA-induced hyperthermia must also be considered.