Niveles de células progenitoras endoteliales circulantes en pacientes hipertensos tratados

  1. C. Maroun-Eid 1
  2. A. Ortega-Hernández 1
  3. M. Abad 1
  4. J.A. García-Donaire 1
  5. A. Barbero 1
  6. L. Reinares 1
  7. N. Martell-Claros 1
  8. D. Gómez-Garre 1
  1. 1 Hospital Clínico San Carlos de Madrid
    info

    Hospital Clínico San Carlos de Madrid

    Madrid, España

    ROR https://ror.org/04d0ybj29

Journal:
Hipertensión y riesgo vascular

ISSN: 1889-1837

Year of publication: 2015

Volume: 32

Issue: 4

Pages: 142-150

Type: Article

DOI: 10.1016/J.HIPERT.2015.07.002 DIALNET GOOGLE SCHOLAR

More publications in: Hipertensión y riesgo vascular

Abstract

Introduction Most optimally treated hypertensive patients still have an around 50% increased risk of any cardiovascular event, suggesting the possible existence of unidentified risk factors. In the last years there has been evidence of the essential role of circulating endothelial progenitor cells (EPCs) in the maintenance of endothelial integrity and function, increasing the interest in their involvement in cardiovascular disease. In this study, the circulating levels of EPCs and vascular endothelial growth factor (VEGF) are investigated in treated hypertensive patients with adequate control of blood pressure (BP). Material and methods Blood samples were collected from treated hypertensive patients with controlled BP. Plasma levels of EPCs CD34+/KDR+ and CD34+/VE-cadherin+ were quantified by flow cytometry. Plasma concentration of VEGF was determined by ELISA. A group of healthy subjects without cardiovascular risk factors was included as controls. Results A total of 108 hypertensive patients were included (61±12 years, 47.2% men) of which 82.4% showed BP < 140/90 mmHg, 91.7% and 81.5% controlled diabetes (HbA1c <7%) and cLDL (<130 or 100 mg/dL), respectively, and 85.2% were non-smokers. Around 45% of them were obese. Although patients had cardiovascular parameters within normal ranges, they showed significantly lower levels of CD34+/KDR+ and CD34+/VE-cadherin+ compared with healthy control group, although plasma VEGF concentration was higher in patients than in controls. Conclusions Despite an optimal treatment, hypertensive patients show a decreased number of circulating EPCs that could be, at least in part, responsible for their residual cardiovascular risk, suggesting that these cells could be a therapeutic target.

Data source: Dialnet