Biomarcadores salivales como medio diagnóstico para la detección de lesiones potencialmente malignas y cáncer oral
- Víctor Paredes Rodríguez
- Roberto Cecilia Murga
- José González Serrano
- Mariano García-Riart Monzón
- Juan López-Quiles Martínez
- Gonzalo Hernández Vallejo
ISSN: 1697-6398, 1697-641X
Year of publication: 2015
Volume: 12
Issue: 2
Pages: 23-27
Type: Article
More publications in: Científica dental: Revista científica de formación continuada
Abstract
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm in the oral cavity and it is often preceded by a potentially malignant disorder. The diagnosis is based on pathological examination of a biopsy. however, early detection is crucial for a good prognosis. That is why new techniques are being developed for an early diagnosis an exfoliative cytology, staining with toluidine blue, luminescence techniques or salivary biomarkers. This literature review summarizes the salivary biomarkers used for the diagnosis of potentially malignant disorders and oral cancer. Biomarkers are chemicals that can be objectively measured to diagnose, assess response to treatment or recurrence of disease. More than 30 potential salivary biomarkers have been detected for an early detection of OSCC. Although further studies are needed, the combination of several biomarkers may be essential in future researches.