Cardiovascular disease markers responses in male receiving improved-fat meat-products vary by initial ldl-cholesterol levels

  1. Celada, Paloma
  2. Sánchez-Muniz, Francisco José
  3. Delgado-Pando, Gonzalo
  4. Bastida, Sara
  5. Espárrago-Rodilla, Manuel
  6. Jiménez-Colmenero, Francisco
  7. Olmedilla-Alonso, Begoña
Revista:
Journal of Negative and No Positive Results: JONNPR

ISSN: 2529-850X

Año de publicación: 2016

Volumen: 1

Número: 6

Páginas: 229-236

Tipo: Artículo

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Otras publicaciones en: Journal of Negative and No Positive Results: JONNPR

Resumen

AbstractObjectives: Cardiovascular disease (CVD) is prevalent in peoples at high meat-product consumption. To study the effect of consuming different Pâté and Frankfurter formulations on clinical/emergent CVD biomarkers in male volunteers with different initial LDL-cholesterol levels (< and ³ 3.36 mmol/L).Method: Eighteen male volunteers with at least two CVD risk factors were enrolled in a sequentially controlled study. Pork-products were consumed during 4wk: reduced-fat (RF), omega-3-enriched-RF (n-3RF), and normal-fat (NF). Pork-products were separated by 4wk washout. Lipids, lipoproteins, oxidized LDL (oxLDL), apolipoproteins (apo) and their ratios, homocysteine (tHcys), arylesterase (AE), C-reactive protein (CRP), tumor necrotic factor (TNFa) were tested.Results: The rate of change for AE, oxLDL, Lp(a), AE/HDL-cholesterol, LDL/apo B and AE/oxLDL ratios varied (p<0.05) among periods only in volunteers with LDL-cholesterol ³3.36 mmol/L. TNFa decreased (p<0.05) among volunteers with low-normal LDL-cholesterol values while AE increased (p<0.01) in high LDL-cholesterol volunteers during the RF-period. AE increased while CRP decreased (both p<0.01) in low-normal LDL-cholesterol volunteers while AE (p<0.001) and apo B (p<0.01) increased in the high LDL-cholesterol group during the n-3RF-period. Total cholesterol (p<0.05) increased in the low/normal LDL-cholesterol group while tHcys decreased (p<0.05) in the high LDL-cholesterol group during the NF-period. Differences in response in volunteers with low-normal vs. high initial LDL-cholesterol levels to the n-3RF but not to the RF meat-products were evident.Conclusions: Subjects with high LDL-cholesterol seems target for n-3RF products while subjects with LDL-cholesterol <3.36 mmol/L were more negatively affected by NF-products. Any generalization about functional meat product or consumption should be avoided.

Referencias bibliográficas

  • Celada P, Bastida S, Sánchez-Muniz FJ. To eat or not to eat meat. That is the question. Nutr Hosp. 2016;33:177-
  • Celada P, Sánchez-Muniz FJ. Are meat and meat product consumptions harmful? Their relationship with the risk
  • of colorectal cancer and other degenerative diseases. An Real Acad Farm. 2016;82 (1):68-90.
  • AESAN ENIDE: Encuesta Nacional de Ingesta Dietética (2009-2010). Evaluación nutricional de la dieta española.
  • I. Energía y macronutrientes, 2011,
  • http://aesan.msssi.gob.es/AESAN/web/notas_prensa/presentacion_enide.shtml
  • Delgado-Pando G, Celada P, Sánchez-Muniz FJ, Jiménez-Colmenero F, Olmedilla-Alonso B. Effects of improved
  • fat content of frankfurters and pâtés on lipid and lipoprotein profile of volunteers at increased cardiovascular risk:
  • a placebo-controlled study. Eur J Nutr. 2014;53:83-93.
  • Celada P, Delgado-Pando G, Olmedilla-Alonso B, Jiménez-Colmenero F, Ruperto M, Sánchez-Muniz FJ. Impact
  • of improved fat-meat products consumption on anthropometric markers and nutrient intakes of male volunteers at
  • increased cardiovascular risk. Nutr Hosp. 2015;32(2):710-721.
  • Celada P, Sánchez-Muniz FJ, Delgado-Pando G, Bastida S, Espárrago-Rodilla M, Jiménez-Colmenero F,
  • Olmedilla-Alonso B. Effects of improved fat meat products consumption on emergent cardiovascular disease
  • markers of male volunteers at cardiovascular risk. J Physiol Biochem. 2016; (Published on line 4 July 2016) DOI
  • s13105-016-0505-5.
  • Beynen AC, Katan MB, Zutphen LHM. Hypo and hyperresponses: individual differences in the response of serum
  • cholesterol concentration to changes in diet. Adv Lip Res. 1987;22:115-171.
  • Cuesta C, Ródenas S, Merinero MC, Rodríguez-Gil S, Sánchez-Muniz FJ. Lipoprotein profiles and serum
  • peroxide levels of aged women consuming palmolein or oleic acid-rich sunflower oil diets. Eur J Clin Nutr.
  • ;52(9):675-683.
  • Sánchez-Muniz FJ, Maki KC, Shaefer EJ, Ordovás JM. Serum lipid and antioxidant responses in
  • hypercholesterolemic men and women receiving plant sterol esters vary by apoliprotein E genotype. J Nutr.
  • ;139:1-7.
  • Mensink RP, Aro A, Den Hond E, German JB, Griffin BA, Meer HU, Mutanen M, Pannemans D, Stahl W. Dietrelated
  • cardiovascular disease. Eur J Nutr. 2003;42:I/6-I/27.
  • Delgado-Pando G, Cofrades S, Ruiz-Capillas C, Jiménez-Colmenero F. Healthier lipid combination as functional
  • ingredient influencing sensory and technological properties of low-fat frankfurters. Eur J Lipid Sci Technol.
  • ;112: 59-870.
  • Delgado-Pando G, Cofrades S, Rodríguez-Salas L, Jiménez-Colmenero F. A healthier oil combination and konjac
  • gel as functional ingredients in low-fat pork liver pâté. Meat Sci. 2011;88:241-248.
  • Nus M, Sánchez-Muniz FJ, Sánchez-Montero JM. A new method for the determination of arylesterase activity in
  • human serum using simulated body fluid. Atherosclerosis. 2006;188:155-159.
  • Nus M, Frances F, Librelotto J, Canales A, Corella D, Sánchez-Montero JM, Sánchez-Muniz FJ. Arylesterase
  • activity and antioxidant status depend on PON1-Q192R and PON1-L55M polymorphisms in subjects with
  • increased risk of cardiovascular disease consuming walnut-enriched meat. J Nutr. 2007;137(7):1783-1788.
  • Palomaki A, Pohjantahti-Maaroos H, Wallenius M, KankkunenP, Aro H, Husgafvel S, Pihlava JM, Oksanen K.
  • Effects of dietary cold-pressed turnip rapeseed oil and butter on serum lipids, oxidized LDL and arterial elasticity
  • in men with metabolic syndrome. Lipids Health Dis. 2010;9:137.
  • Carmena R. Dyslipidemia. In: Serrano-Ríos, Gutiérrez-Fuentes (eds). Type 2 Diabetes Mellitus. Amsterdam:
  • Elsevier; 2010, pp. 219-230.
  • Harris WS, Miller M, Tighe AP, Davidson MH, Schaefer EJ. Omega-3 fatty acids and coronary heart disease risk:
  • clinical and mechanistic perspectives. Atherosclerosis. 2008;197:12-24.
  • Kurt B, Soufi M, Sattler A, Schaefer JR. The only established Lp(a) lowering treatment is the use of nicotinic acid,
  • fibrates or performing LDL/Lp(a) apheresis Lipoprotein(a)-clinical aspects and future challenges. Clin Res Cardiol.
  • ;Suppl;10:26-32.
  • Haring B, von Ballmoos MC, Appel LJ, Sacks FM. Healthy dietary interventions and lipoprotein (a) plasma levels:
  • results from the Omni Heart Trial. PLoS One. 2014;9(12):e114859.
  • Shin MJ, Blanche PJ, Rawlings RS, Fernstrom HS, Krauss RM. Increased plasma concentrations of lipoprotein(a)
  • during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein CIII
  • bound to apolipoprotein B-containing lipoproteins. Am J Clin Nutr. 2007,85:1527-1532.
  • Berglund L, Lefevre M, Ginsberg HN, Kris-Etherton PM, Elmer PJ, Stewart PW, Ershow A, Pearson TA, Dennis
  • BH, Roheim PS, Ramakrishnan R, Reed R, Stewart K, Phillips KM. Comparison of monounsaturated fat with
  • carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the
  • fasting and postprandial states. Am J Clin Nutr. 2007;86:1611-1620.
  • Trpkovic A, Resanovic I, Stanimirovic J, Radak D, Mousa SA, Cenic-Milosevic D, Jevremovic DA, Isenovic, ER.
  • Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Crit Rev Clin Lab Sci. 2015;52(2):70-
  • Bastida S, Perea S, Sánchez-Muniz FJ. Do neonates with high serum cholesterol levels have a different high
  • density lipoprotein composition? Eur J Pediatr. 1998;157(1):66-70.
  • Culebras JM. Resultados negativos, cincuenta por ciento del conocimiento. JONNPR. 2016;1(1):1-2.
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