Genetic association study within the framework of Zuckerman's psychobiological personality model

  1. Luis F. García 1
  2. Anton Aluja 2
  3. Oscar García 2
  4. Lara Cuevas 3
  1. 1 Universidad Autónoma de Madrid, España
  2. 2 Institut of Biomedical Research of Lleida, España
  3. 3 Complutense University of Madrid, España
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Revista:
Anuario de psicología

ISSN: 0066-5126

Ano de publicación: 2016

Volume: 46

Número: 1

Páxinas: 17-30

Tipo: Artigo

DOI: 10.1016/J.ANPSIC.2016.06.003 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Anuario de psicología

Resumo

Following Zuckerman's psychobiological personality model, a series of genetic association hypotheses between some polymorphisms of Serotonin, Testosterone, Dopamine, MAO-A and COMT, and three temperamental traits (Impulsive Unsocialized Sensation Seeking, Neuroticism, and Extroversion-Sociability) were tested. In order to surpass previous limitations of this kind of studies: 1) the measurement of the phenotype was improved by using eight personality scales, and 2) some statistical analyses were conducted to test conjointly the effects of the considered polymorphisms. 252 participants from two samples (147 male inmates, and 105 male healthy volunteers) were analyzed. A tendency in the theoretical expected direction is reported when several polymorphisms are considered conjointly. The discussion section recommends applying more integrative frameworks to explore the complex paths from genetics to behavior.

Referencias bibliográficas

  • Aluja, A., & Blanch, A. (2011). Neuropsychological behavioral inhibition system (BIS) and behavioral approach system (BAS) assessment: A shortened sensitivity to punishment and sensitivity to reward questionnaire version (SPSRQ-20). Journal of Personality Assessment, 93(6), 628-636.
  • Aluja, A., & Garcia, L. F. (2005). Sensation seeking, sexual curiosity and testosterone in inmates. Neuropsychobiology, 51(1), 28-33.
  • Aluja, A., Garcia, L. F., Blanch, A., De Lorenzo, D., & Fibla, J. (2009). Impulsive-desinhibited personality traits and serotonin transporter gene polymorphisms: Association study in an inmates sample. Journal of Psychiatric Research, 43, 906-914.
  • Aluja, A., Garcia, L. F., Blanch, A., & Fibla, J. (2011). Association of androgen receptor gene, CAG and GGN repeat length polymorphism and impulsive-disinhibited personality traits in inmates: The role of short-long haplotype. Psychiatric Genetics, 21(5), 229-239.
  • Aluja, A., Garcia, L. F., Cuevas, L., & Garcia, O. (2007). Zuckerman's personality model predicts MCMI-III personality disorders. Personality and Individual Differences, 42, 1311-1321.
  • Aluja, A., Garcia, O., & Garcia, L. F. (2002). A comparative study of Zuckerman's three structural models for personality through the NEO-PI-R, ZKPQ-III-R, EPQ-RS and goldberg's 50-bipolar adjectives. Personality and Individual Differences, 33(5), 713-726.
  • Aluja, A., Garcia, O., & Garcia, L. F. (2003). Psychometric properties of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ- III-R): A study of a shortened form. Personality and Individual Differences, 34(7), 1083-1097.
  • Archer, J. (2006). Testosterone and human aggression: An evaluation of the challenge hypothesis. Neuroscience and Biobehavioral Reviews, 30(3), 319-345.
  • Azmitia, E. C., & Whitaker-Azmitia, P. M. (1995). Anatomy, cell biology and plasticity of the serotonergic system. In F. E. Bloom, & D. J. Kupfer (Eds.), Psychopharmacology: A fourth generation of progress (pp. 443-449). New York: Raven Press.
  • Barratt, E. S. (1985). Impulsiveness subtraits: Arousal and information processing. In J. T. Spence, & C. E. Itard (Eds.), Motivation, emotion and personality (pp. 137-146). Amsterdam: Elsevier.
  • Benjamin, J., Ebstein, R. P., & Belmaker, R. H. (2002). Molecular genetics and the human personality. Washington, D.C: American Psychiatric Publishing.
  • Bennett, A. J., Lesch, K. P., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., Higley, J. D. (2002). Early experience and serotonin transporter gene variation interact to influence primate CNS function. Molecular Psychiatry, 7(1), 118-122.
  • Burt, S. A., McGue, M., Iacono, W., Comings, D., & MacMurray, J. (2002). An examination of the association between DRD4 and DRD2 polymorphisms and personality traits. Personality and Individual Differences, 33(6), 849-859.
  • Calati, R., Porcelli, S., Giegling, I., Hartmann, A. M., Moller, H. J., De Ronchi, D., Rujescu, D. (2011). Catechol-o-methyltransfer-Ase gene modulation on suicidal behavior and personality traits: Review, meta-Analysis and association study. Journal of Psychiatric Research, 45(3), 309-321.
  • Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science (New York, N.Y.), 297(5582), 851-854.
  • Chen, J., Lipska, B. K., Halim, N., Ma, Q. D., Matsumoto, M., Melhem, S., Weinberger, D. R. (2004). Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): Effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics, 75(5), 807-821.
  • Comings, D. E., Chen, C., Wu, S., & Muhleman, D. (1999). Association of the androgen receptor gene (AR) with ADHD and conduct disorder. Neuro Report: For Rapid Communication of Neuroscience Research, 10(7), 1589-1592.
  • Costa, P. T., & MacCrae, R. R. (1999). Inventario de personalidad neo revisado (NEO PI-R) inventario neo reducido de cinco facto- res (NEO-FFI): manual profesional. Madrid: Tea.
  • Ding, D., Xu, L., Menon, M., Reddy, G. P., & Barrack, E. R. (2005). Effect of GGC (glycine) repeat length polymorphism in the human androgen receptor on androgen action. The Prostate, 62(2), 133-139.
  • Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Weinberger, D. R. (2001). Effect of COMT Val108/158 met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 98(12), 6917-6922.
  • Eysenck, H. J., & Eysenck, S. B. G. (1997). Eysenck personality questionnaire-revised (EPQ-R) and short scale (EPQ-RS). Madrid: TEA Ediciones.
  • Fanselow, M. S. (1994). Neural organization of the defensive behavior system responsible for fear. Psychonomic Bulletin & Review, 1(4), 429-438.
  • Fowler, T., Langley, K., Rice, F., van den Bree, M. B., Ross, K., Wilkinson, L. S., Thapar, A. (2009). Psychopathy trait scores in adolescents with childhood ADHD: The contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics, 19(6), 312-319.
  • Garcia, L. F., Aluja, A., Fibla, J., Cuevas, L., & Garcia, O. (2010). Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. Psychiatry Research, 177(1-2), 161-166.
  • Halligan, P. W., Kischka, U., & Marshall, J. C. (2004). Handbook of clinical neuropsychology. New York: Oxford University Press.
  • Hamer, D. (2002). Genetics rethinking behavior genetics. Science (New York, N.Y.), 298(5591), 71-72.
  • Hamidovic, A., Dlugos, A., Skol, A., Palmer, A. A., & de Wit, H. (2009). Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensa-Tion seeking: An exploratory study with d-Amphetamine in healthy participants. Experimental and Clinical Psychopharmacology, 17(6), 374-383.
  • Huang, Y. Y., Cate, S. P., Battistuzzi, C., Oquendo, M. A., Brent, D., & Mann, J. J. (2004). An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 29(8), 1498-1505.
  • Jacob, C. P., Muller, J., Schmidt, M., Hohenberger, K., Gutknecht, L., Reif, A., Lesch, K. P. (2005). Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 30(9), 1711-1718.
  • Jonsson, E. G., von Gertten, C., Gustavsson, J. P., Yuan, Q., Lindblad-Toh, K., Forslund, K., Schalling, M. (2001). Androgen receptor trinucleotide repeat polymorphism and personality traits. Psychiatric Genetics, 11(1), 19-23.
  • Kagan, J., & Snidman, S. (2007). Temperament and biology. In D. Coch, K. W. Fischer & G. Dawson (Eds.), Human behavior, learning, and the developing brain (pp. 219-246). New York: The Guil- frod Press.
  • Kaiser, R., Muller-Oerlinghausen, B., Filler, D., Tremblay, P. B., Berghofer, A., Roots, I., & Brockmoller, J. (2002). Correlation between serotonin uptake in human blood platelets with the 44-bp polymorphism and the 17-bp variable number of tandem repeat of the serotonin transporter. American Journal of Medical Genetics, 114(3), 323-328.
  • Kittles, R. A., Young, D., Weinrich, S., Hudson, J., Argyropoulos, G., Ukoli, F., Dunston, G. M. (2001). Extent of linkage disequilibrium between the androgen receptor gene CAG and GGC repeats in human populations: Implications for prostate cancer risk. Human Genetics, 109(3), 253-261.
  • Lachman, H. M., Nolan, K. A., Mohr, P., Saito, T., & Volavka, J. (1998). Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. The American Journal of Psychiatry, 155(6), 835-837.
  • Lesch, K., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Murphy, D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274(5292), 1527-1531.
  • Loehlin, J. C. (1992). Genes and environment in personality development. Newbury Park etc.: Sage.
  • Loehlin, J. C. (2003). Latent variable models an introduction to factor, path, and structural analysis (4th ed.). Hillsdale, New Jersey: Lawrence Erlbaum.
  • Luengo, M. A., Carrillo-De-La-Pena, M. T., & Otero, J. M. (1991). The components of impulsiveness: A comparison of the I.7 impulsiveness questionnaire and the barratt impulsiveness scale. Personality and Individual Differences, 12(7), 657-667.
  • Manuck, S. B., Flory, J. D., Ferrell, R. E., Mann, J. J., & Muldoon, M. F. (2000). A regulatory polymorphism of the monoamine oxi- dase-A gene may be associated with variability in aggression, im- pulsivity, and central nervous system serotonergic responsivity. Psychiatry Research, 95(1), 9-23.
  • Matthews, G., & Deary, I. J. (1998). Personality traits. Cambridge: University Press.
  • Munafo, M. R., Matheson, I. J., & Flint, J. (2007). Association of the DRD2 gene TAQ1A polymorphism and alcoholism: A meta-Analysis of case-control studies and evidence of publication bias. Molecular Psychiatry, 12(5), 454-461.
  • Munafo, M. R., Clark, T. G., Moore, L. R., Payne, E., Walton, R., & Flint, J. (2003). Genetic polymorphisms and personality in healthy adults: A systematic review and meta-Analysis. Molecular Psychiatry, 8(5), 471-484.
  • Reuter, M., Schmitz, A., Corr, P., & Hennig, J. (2006). Molecular genetics support gray's personality theory: The interaction of COMT and DRD2 polymorphisms predicts the behavioural ap-proach system. The International Journal of Neuropsychopharmacology/Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 9(2), 155-166.
  • Roberti, J. W. (2004). A review of behavioral and biological correlates of sensation seeking. Journal of Research in Personality, 38(3), 256-279.
  • Rujescu, D., Giegling, I., Gietl, A., Hartmann, A. M., & Moller, H. J. (2003). A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits. Biological Psychiatry, 54(1), 34-39.
  • Sabol, S. Z., Hu, S., & Hamer, D. (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103(3), 273-279.
  • Shih, J. C., Chen, K., & Ridd, M. J. (1999). Monoamine oxidase: From genes to behavior. Annual Review of Neuroscience, 22, 197-217.
  • Stelmack, R. M. (2004). On the psychobiology of personality, essays in honor of marvin zuckerman. Londres: Pergamon.
  • Strobel, A., Lesch, K. P., Jatzke, S., Paetzold, F., & Brocke, B. (2003) Further evidence for a modulation of novelty seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants. Molecular Psychiatry, 8(4), 371-372.
  • Tikkanen, R., Auvinen-Lintunen, L., Ducci, F., Sjoberg, R. L., Goldman, D., Tiihonen, J., Virkkunen, M. (2011). Psychopathy, PCL-R, and MAOA genotype as predictors of violent reconvictions. Psychiatry Research, 185(3), 382-386.
  • Torrubia, R., Avila, C., Molto, J., & Caseras, X. (2001). The sensitivity to punishment and sensitivity to reward questionnaire (SPSRQ) as a measure of gray's anxiety and impulsivity dimensions. Personality and Individual Differences, 31(6), 837-862.
  • Tsai, S. J., Hong, C. J., Yu, Y. W., & Chen, T. J. (2004). Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young chinese females. Neuropsychobiology, 50(2), 153-156.
  • Tunbridge, E. M., Weickert, C. S., Kleinman, J. E., Herman, M. M., Chen, J., Kolachana, B. S., Weinberger, D. R. (2007). Catechol- o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. Cerebral Cortex (New York, N.Y.: 1991), 17(5), 1206-1212.
  • Turakulov, R., Jorm, A. F., Jacomb, P. A., Tan, X., & Easteal, S. (2004) Association of dopamine -p- hydroxylase and androgen receptor gene polymorphisms with eysenck's P and other personality traits. Personality and Individual Differences, 37(1), 191-202.
  • Volavka, J., Bilder, R., & Nolan, K. (2004). Catecholamines and aggression: The role of COMT and MAO polymorphisms. Annals of the New York Academy of Sciences, 1036, 393-398.
  • Zuckerman, M. (1994). Behavioural expressions and biosocial bases of sensation-seeking. Cambridge: Cambridge University Press.
  • Zuckerman, M. (2005). Psychobiology of personality (2nd ed.). Cambridge: Cambridge University Press.
  • Zuckerman, M., & Aluja, A. (2014). Measures of sensation seeking. In G. J. Boyle, D. H. Saklofske & G. Matthews (Eds.), Measures of personality and social psychological constructs. (pp. 352-380). San Diego: Academic Press.
  • Zuckerman, M., Kuhlman, D. M., Joireman, J., Teta, P., & Kraft, M. (1993). A comparison of three structural models for personality: The big three, the big five, and the alternative five. Journal of Personality and Social Psychology, 65(4), 757-768.
  • Zuckerman, M., Kuhlman, D. M., Thornquist, M., & Kiers, H. (1991). Five (or three) robust questionnaire scale factors of personality without culture. Personality and Individual Differences, 12(9), 929-941.
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