Estomatitis aftosa recidivanterevisión y puesta al día

Laburpena

Recurrent aphthous stomatitis (RAS), also known as recurren/ oral ulcers or «canker so re, » is a chronic inflammato ry disease characterized by the onset of one or more painful ulcers (aphthae) on the oral mucosa, usually on non-keratinized zanes, with a non-especific histopathology, persisting severa[ days or even weeks, and recurring after variable remission periods. RAS is the most common condition affecting th e oral but the cause remains unknown.. Severa/ fa ctors, including genetic, infectious, immun.ologic, local an.d systemic on.es, have been proposed as possible pathogenic mechanism. There may be a genetic basis with a mild immun.e dysregulation. RAS has three clinical forms, accordin.g to the size of the lesions: minar, majar an.d herpetifo rm. The histopathology is non-specific and other complementary tests are n.ot helpful, so the diagnosis is made on a clinical basis. RAS may be associated with so me systemic conditions like Beh(:et 's disease, in which a triad of oral ulcers, genital ulcers and ocular lesions typically occurs. RAS has no specific treatmen.t, and only symptomatic therapies can be applied. A greclf variety of treatments ha ve been u sed including topical therapies ( antiseptics, an.tibiotics, corticoids) and systemic therapies ( corticoids, thalidomide, immunomodulators, among many others) but only pain relief and dela y of the recurrences can be achieved. Its importance far the dentist and far the gen.eral practitioner is based on its high prevalence, the patient 's discomfo rt an.d the lack of a specific treatment to resolve the problem