Peri-implant bone mechanobiology. Review of the literature

  1. Vanesa Badillo Perona
  2. Jorge Cano Sánchez
  3. Julián Campo Trapero
  4. Antonio Bascones Martínez
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Year of publication: 2011

Volume: 16

Issue: 5

Pages: 8

Type: Article

DOI: 10.4317/MEDORAL.1705 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Medicina oral, patología oral y cirugía bucal. Ed. inglesa


The mechanical load applied during bone regeneration in implant treatments influences the early formation of peri-implant bone tissue through the activation of different pathways. The aim of this review was to determine the currently available scientific evidence in this field.Material and method: lectronic search in medical databases (Medline, Pubmed and Cochrane ibrary) of eperimental studies in animal models published from 2003 to 2009. Results: There is scientific evidence that the immediate application of an axial load in implantology stimulates bone formation, as measured by various histomorphometric parameters. Different physiological mechanisms (e.g., production of nitric oxide, prostaglandin E2) participate in this effect, although their action has not been fully elucidated. Conclusion: The precise role of mechanical loading in the osseointegration process remains unknown. Further studies are required to demonstrate the biological mechanisms involved and the load range producing the most effective response and to develop devices for obtaining predictable clinical outcomes. © Medicina Oral.