Retrospective study of 149 cases of salivary gland carcinoma in a Spanish hospital population

  1. Lucía Collazo Fernández 1
  2. Julián Campo Trapero 2
  3. Jorge Cano Sánchez 3
  4. Rosa García Martín 4
  5. Claudio Ballestín Carcavilla 5
  1. 1 DDS, MSD, Doctorate student. School of Dentistry, Complutense University of Madrid
  2. 2 DDS, PhD, Lecturer. Department of Medicine and Orofacial Surgery, School of Dentistry, Complutense University of Madrid
  3. 3 DDS, PhD, Private Activity. Specialist in Oral Surgery, UK
  4. 4 Biologist. Department of Pathology of the 12 de Octubre Hospital of Madrid, Madrid
  5. 5 MD, PhD, Physician. Department of Pathology of the 12 de Octubre Hospital of Madrid
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Year of publication: 2017

Volume: 22

Issue: 2

Pages: 10

Type: Article

DOI: 10.4317/MEDORAL.21419 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Sustainable development goals


The clinical and histological characteristics of salivary gland tumors vary widely, complicating their diagnosis and management, and major differences have been recorded in the distribution of histopathological diagnoses among different countries. This retrospective study reviewed the demographic (age, sex) and clinicopathological (pathology diagnosis and localization) characteristics of cases diagnosed with primary SGC between June 1992 and May 2014 in the Pathology Department of the 12 de Octubre Hospital of Madrid. Diagnoses were recorded according to the 2005 WHO classification. The study included 149 SCG patients, aged between 11 and 94 yrs, with mean age at onset of 55.56 yrs and peak incidence in the eighth decade of life. The male:female ratio was 1.01. The parotid gland was the most frequently involved (75.2%). The most frequent carcinoma was mucoepidermoid carcinoma (24.2%), followed by acinic cell carcinoma (15.4%). The demographic and histopathological characteristics of patients with salivary gland carcinomas in Spain, reported here for the first time, are broadly similar to those found in other countries.

Bibliographic References

  • Lukšić, I, Virag, M, Manojlović, S, Macan, D. (2012). Salivary gland tumours: 25 years of experience from a single institution in Croatia. J Craniomaxillofac Surg. 40. 75-81
  • Bhattacharyya, N, Fried, MP. (2005). Determinants of survival in parotid gland carcinoma: a population-based study. Am J Otolaryngol. 26. 39-44
  • Kızıl, Y, Aydil, U, Ekinci, O, Dilci, A, Köybaşıoğlu, A, Düzlü, M. (2013). Salivary gland tumors in Turkey: demographic features and histopathological distribution of 510 patients. Indian J Otolaryngol Head Neck Surg. 651. 112
  • Speight, PM, Barrett, AW. (2002). Salivary gland tumours. Oral Dis. 8. 229
  • Wang, XD, Meng, LJ, Hou, TT, Huang, SH. (2015). Tumours of the salivary glands in northestern China: a retrospective study of 2508 patients. Br J Oral Maxillofac Surg. 53. 132
  • Ito, FA, Ito, K, Vargas, PA, de Almeida, OP, Lopes, MA. (2005). Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases. Int J Oral MaxillofacSurg. 34. 533
  • Al-Khateeb, TH, Ababneh, KT. (2007). Salivary tumors in north Jordanians: a descriptive study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 103. 53
  • de Souza, DL, Bernal, MM, Curado, MP. (2012). [Trends in the incidence of major salivary gland cancer in Spain (1978-2002)]. Gac Sanit. 26. 65
  • Davies, L, Welch, HG. (2006). Epidemiology of head and neck cancer in the United States. Otolaryngol Head Neck Surg. 135. 451
  • Li, LJ, Li, Y, Wen, YM, Liu, H, Zhao, HW. (2008). Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol. 44. 187
  • Bell, RB, Dierks, EJ, Homer, L, Potter, BE. (2005). Management and outcome of patients with malignant salivary gland tumors. J Oral Maxillofac Surg. 63. 917
  • Subhashraj, K. (2008). Salivary gland tumors: a single institution experience in India. Br J Oral Maxillofac Surg. 46. 635
  • Tilakaratne, WM, Jayasooriya, PR, Tennakoon, TM, Saku, T. (2009). Epithelial salivary tumors in Sri Lanka: a retrospective study of 713 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 108. 90
  • Kara, MI, Göze, F, Ezirganli, S, Polat, S, Muderris, S, Elagoz, S. (2010). Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal. 15. 880
  • Tian, Z, Li, L, Wang, L, Hu, Y, Li, J. (2010). Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective STUDY of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 39. 235
  • Lawal, AO, Adisa, AO, Kolude, B, Adeyemi, BF, Olajide, MA. (2013). A REVIEW of 413 salivary gland tumors in the head and neck region. J ClinExpDent. 5. 218
  • Fonseca, FP, Carvalho, MdeV, de Almeida, OP, Rangel, AL, Takizawa, MC, Bueno, AG. (2012). Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral Surg Oral Med Oral Pathol Oral Radiol. 114. 230
  • Jones, AV, Craig, GT, Speight, PM, Franklin, CD. (2008). The range and demographics of salivary gland tumours diagnosed in a UK population. Oral Oncol. 44. 407
  • Mejía-Velázquez, CP, Durán-Padilla, MA, Gómez-Apo, E, Quezada-Rivera, D, Gaitán-Cepeda, LA. (2012). Tumors of the salivary gland in Mexicans. A retrospective STUDYof 360 cases. Med Oral Patol Oral Cir Bucal. 17. 183
  • Ostman, J, Anneroth, G, Gustafsson, H, Tavelin, B. (1997). Malignant salivary gland tumours in Sweden 1960-1989-an epidemiological study. Oral Oncol. 33. 169
  • Ansari, MH. (2007). Salivary gland tumors in an Iranian population: a retrospective study of 130 cases. J Oral Maxillofac Surg. 65. 2187
  • Saghravanian, N, Ghazi, N, Saba, M. (2013). Clinicopathologic evaluation of salivary gland neoplasms: a 38-year retrospective STUDY in Iran. Ann Diagn Pathol. 17. 522
  • De Araujo, VC, Passador-Santos, F, Turssi, C, Soares, AB, de Araujo, NS. (2013). Polymorphous low-grade adenocarcionma: an analysis of epidemiological studies and hints for phatologist. Diagn pathol. 8. 6
  • Anderson, JN Jr, Beenken, SW, Crowe, R, Soong, SJ, Peters, G, Maddox, WA. (1995). Prognostic factors in minor salivary gland cancer. Head Neck. 17. 480