Tumor de células granulares (tumor de Abrikossoff) en la lengua. A propósito de un caso y revisión de la literatura

Abstract

Introduction: Granular cell tumor is a soft tissue neoplasm that usually affects females in the fourth to sixth decades of life. It can affect any area of the body, with preponderance to the oral cavity, specifically in the tongue, as an asymptomatic nodule of slow growth. Histological findings, differential diagnosis and therapeutic implications are discussed together with a review of the literature. Case report: A 21 year old female comes to the Oral Surgery and Medicine Department of the Complutense university of Madrid because of an asymptomatic lesion in the tongue of a year of evolution. The final diagnosis after exisional biopsy was granular cell tumor. Discussion: Firstly described as “granular cell myoblastoma”, different terms have been applied to this entity such as “granular cell neurofibroma” or “granular cell schwannoma”. The theory of a neural origin of the granular cells based on inmunohistochemical studies is now accepted. Its usual benign behavior and its low recurrence rate after surgical excision set a favorable prognosis. Conclusion: A surgical excisional biopsy of the tumor and histological examination are necessary for the correct diagnosis and treatment due to differential diagnosis including benign soft tissue tumors.