‘Reliability of new poly (lactic-co-glycolic acid) membranes treated with oxygen plasma plus silicon dioxide layers for pre-prosthetic guided bone regeneration processes’

  1. Gabriel Castillo Dalí 1
  2. Raquel Castillo de Oyagüe 2
  3. Antonio Batista Cruzado 1
  4. Carmen López Santos 3
  5. Agustín Rodríguez González-Elipe 3
  6. Jean Louis Saffar 4
  7. Christopher D. Lynch 5
  8. José Luis Gutiérrez Pérez 1
  9. Daniel Torres Lagares 1
  1. 1 Dr. Biol, PhD. DDS. DMD, PhD. DDS, PhD. Department of Stomatology, Faculty of Dentistry, University of Seville (US), C/ Avicena, s/n, 41009, Seville, Spain
  2. 2 DDS, PhD. Department of Buccofacial Prostheses, Faculty of Dentistry, Complutense University of Madrid (UCM), Pza. Ramón y Cajal, s/n, 28040, Madrid, Spain
  3. 3 Dr. Phys. PhD. DDS. Institute of Materials Science of Seville (CSIC-University of Seville), C/ Américo Vespucio, 49, 41092, Seville, Spain
  4. 4 DDS, PhD Faculté de Chirurgie Dentaire, Université Paris V – Descartes, rue Maurice Arnoux, no. 1, 92120, Montrouge, Paris, Franc
  5. 5 BDS, PhD, MFD, FDS (Rest Dent), FACD, FHEA. School of Dentistry, Cardiff University, CF14 4XY, Cardiff, Wales, U.K
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Revista:
Medicina oral, patología oral y cirugía bucal. Ed. inglesa

ISSN: 1698-6946

Año de publicación: 2017

Volumen: 22

Número: 2

Páginas: 15

Tipo: Artículo

DOI: 10.4317/MEDORAL.21512 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa

Resumen

The use of cold plasmas may improve the surface roughness of poly(lactic-co-glycolic) acid (PLGA) membranes, which may stimulate the adhesion of osteogenic mediators and cells, thus accelerating the biodegradation of the barriers. Moreover, the incorporation of metallic-oxide particles to the surface of these membranes may enhance their osteoinductive capacity. Therefore, the aim of this paper was to evaluate the reliability of a new PLGA membrane after being treated with oxygen plasma (PO2) plus silicon dioxide (SiO2) layers for guided bone regeneration (GBR) processes. Circumferential bone defects (diameter: 11 mm; depth: 3 mm) were created on the top of eight experimentation rabbits’ skulls and were randomly covered with: (1) PLGA membranes (control), or (2) PLGA/PO2/SiO2 barriers. The animals were euthanized two months afterwards. A micromorphologic study was then performed using ROI (region of interest) colour analysis. Percentage of new bone formation, length of mineralised bone, concentration of osteoclasts, and intensity of ostheosynthetic activity were assessed and compared with those of the original bone tissue. The Kruskal-Wallis test was applied for between-group com Asignificance level of a=0.05 was considered. The PLGA/PO2/SiO2 membranes achieved the significantly highest new bone formation, length of mineralised bone, concentration of osteoclasts, and ostheosynthetic activity. The percentage of regenerated bone supplied by the new membranes was similar to that of the original bone tissue. Unlike what happened in the control group, PLGA/PO2/SiO2 membranes predominantly showed bone layers in advanced stages of formation. The addition of SiO2 layers to PLGA membranes pre-treated with PO2 improves their bone-regeneration potential. Although further research is necessary to corroborate these conclusions in humans, this could be a promising strategy to rebuild the bone architecture prior to rehabilitate edentulous areas.

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Fuente de los datos: Dialnet