Cambios estructurales del ángulo de la cámara anterior en el glaucoma congénitoComparación con el desarrollo normal

  1. B. Rojas
  2. A.I. Ramírez
  3. R. De-Hoz
  4. J.J. Salazar
  5. J.M. Ramírez
  6. A. Triviño
Revue:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Année de publication: 2006

Volumen: 81

Número: 2

Pages: 65-71

Type: Article

DOI: 10.4321/S0365-66912006000200005 DIALNET GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: Archivos de la Sociedad Española de Oftalmologia

Objetivos de desarrollo sostenible

Résumé

Purpose: To compare findings of normal angles with those from primary congenital glaucoma in order to clarify the pathogenic mechanisms of the disease and to explain the success of surgical treatment in some of these patients. Methods: Adult normal eyes from cadavers and fragments of surgical trabeculectomies from patients with primary congenital glaucoma previously treated with goniotomy were studied. Eyes were processed for examination using light microscopy and scanning electron microscopy techniques. Results: The following was evident in congenital glaucoma: 1) high iris insertion; 2) no observable pre-trabecular membrane, but enlarged trabeculae with diminished inter-trabecular spaces; 3) Schlemm’s canal (SC) apparently normal, with vacuoles in the wall indicating normal functioning; 4) sectioning of the abnormal trabecular tissue during goniotomy allowed repositioning of the angle structures and hence the appearance of the angular recess. Conclusions: Anomalies of the trabecular structures in primary congenital glaucoma do not always parallel an abnormal development of the SC and the collector channels. This fact could explain the success of goniotomy in this type of glaucoma.

Références bibliographiques

  • Hoskins, HD Jr, Shaffer, RN, Hetherington, J. (1984). Anatomical classification of the developmental glaucomas. Arch Ophthalmol. 102. 1331-1336
  • Barkan, O. (1955). Pathogenesis of congenital glaucoma: gonioscopic and anatomic observation of the angle of the anterior chamber in the normal eye and in congenital glaucoma. Ophthalmology. 40. 1-11
  • Worst, JG. (1968). Congenital glaucoma: Remarks on the aspect of chamber angle, ontogenic and pathogenic background, and mode of action of goniotomy. Invest Ophthalmol. 7. 127-134
  • Allen, L, Burian, HM, Braley, AE. (1955). A new concept of the development of the anterior chamber angle: it’s relationship to developmental glaucoma and other structural anomalies. AMA Arch Ophthalmol. 53. 783-798
  • Shaffer, RN. (1955). Pathogenesis of congenital glaucoma: gonioscopic and microscopic anatomy. Trans Am Acad Ophthalmol Otolaryngol. 59. 297-308
  • Maumenee, AE. (1959). The pathogenesis of congenital glaucoma: a new theory. Am J Ophthalmol. 47. 827-859
  • Hara, K. (1977). Basic and clinical studies on glaucoma in childhood: Part 5. Fine structure of the trabecular meshwork in congenital glaucoma. Nippon Ganka Gakkai Zasshi. 81. 995-1005
  • Maul, E, Strozzi, L, Muñoz, C, Reyes, C. (1980). The outflow pathway in congenital glaucoma. Am J Ophthalmol. 89. 667-673
  • Tawara, A, Inomata, H. (1981). Developmental immaturity of the trabecular meshwork in congenital glaucoma. Am J Ophthalmol. 92. 508-525
  • Crombie, AL, Cullen, JF. (1964). Hereditary glaucoma occurrence in five generations of an Edimburgh family. Br J Ophthalmol. 48. 143-147
  • Anderson, DR. (1981). The development of the trabecular meshwork and its abnormality in primary infantile glaucoma. Trans Am Ophthalmol Soc. 79. 458-485
  • Katai, N, Urakawa, Y, Sato, Y, Miyanaga, K, Segawa, K, Yoshimura, N. (1997). CHARGE association with congenital glaucoma due to maldevelopment of the anterior chamber angle. Acta Ophthalmol Scand. 75. 322-324
  • Lin, J, Sun, W, Li, E, Wang, S, Bai, J, Yang, H. (1994). Ultrastructural observations of the anterior chamber angle tissues in congenital glaucoma. Yan Ke Xue Bao. 10. 50-56
  • Sampaolesi, R. (1991). Glaucoma. Panamericana. Buenos Aires.
  • Kupfer, C, Ross, K. (1971). The development of outflow facility in human eyes. Invest Ophthalmol. 10. 513-517
  • Hansson, HA, Jerndal, T. (1971). Scanning electron microscopic studies on the development of the iridocorneal angle in human eyes. Invest Ophthalmol. 10. 252-265
  • Lalive d'Epinay, S. (1980). Congenital glaucoma: Clinical, therapeutic and histological aspects. Adv Ophthalmol. 41. 1-89
  • Manschot, WA. (1970). Juxtapapillary retinal angiomatosis--histology of congenital glaucoma-transverse ischaemic optic nerve necrosis in neuroblastoma. Ophthalmologica. 160. 326-329
  • Broughton, WL, Fine, BS, Zimmerman, LE. (1981). Congenital glaucoma associated with a chromosomal defect: A histologic study. Arch Ophthalmol. 99. 481-486
  • Spencer, WH. (1985). Ophthalmic Pathology: An atlas and text book. WB Saunders Company. Philadelphia.
  • Reme, C, d'Epinay, SL. (1981). Periods of development of the normal human chamber angle. Doc Ophthalmol. 51. 241-268
  • Gorin, G. (1964). Developmental glaucoma: A concept based on correlation of gonioscopic findings with clinical manifestations. Am J Ophthalmol. 58. 572-580