Comorbilidad psiquiátrica y valores plasmáticos de 2-acilgliceroles en consumidores de alcohol en tratamiento ambulatorio. Análisis de las diferencias de género

  1. Nuria García Marchena 1
  2. Pedro Araos 1
  3. Francisco Javier Pavón 1
  4. Guillermo Ponce 2
  5. María Pedraz 1
  6. Antonia Serrano 1
  7. Francisco Arias 2
  8. Pablo Romero-Sanchiz 1
  9. Juan Suárez 1
  10. Antoni Pastor 3
  11. Rafael de la Torre 3
  12. Marta Torrens 3
  13. Gabriel Rubio 1
  14. Fernando Rodríguez de Fonseca 1
  1. 1 Instituto de Investigación Biomédica de Málaga

    Instituto de Investigación Biomédica de Málaga

    Málaga, España


  2. 2 Instituto de Investigación I+12, Hospital 12 de Octubre
  3. 3 INAD
Adicciones: Revista de socidrogalcohol

ISSN: 0214-4840

Year of publication: 2017

Volume: 29

Issue: 2

Pages: 83-96

Type: Article

DOI: 10.20882/ADICCIONES.931 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Adicciones: Revista de socidrogalcohol


Alcohol addiction is associated with high psychiatric comorbidity. Objective stratification of patients is necessary to optimize care and improve prognosis. The present study is designed to gain insights into this challenge by addressing the following objectives: a) to estimate the prevalence of psychiatric comorbidities in a sample of outpatients seeking treatment for alcohol use disorder, b) to describe the existence of gender differences and c) to validate 2-acyl-glycerols as biomarkers of alcohol use disorder and/or psychiatric comorbidity. One hundred and sixty-two patients were recruited and evaluated with the semistructured interview PRISM. The presence of psychopathology was associated with a greater number of criteria for alcohol abuse and dependence according to DSM-IV-TR. We found gender differences in psychiatric comorbidity, e.g., mood disorder, as well as in comorbid substance use disorders. The prevalence of lifetime psychiatric comorbidity was 68.5%, with mood disorders the most frequent (37%), followed by attention deficit disorder (24.7%) and anxiety disorders (17.9%). Substance-induced disorders were more frequent in mood and psychotic disorders, whereas the primary disorders were more prevalent in patients with comorbid anxiety disorders. We found that 2-acyl-glycerols were significantly decreased in comorbid anxiety disorders in alcohol dependent patients in the last year, which makes them a potential biomarker for this psychopathological condition.

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