Host defence mechanisms against bacterial aggression in periodontal diseasebasic mechanisms
- Antonio Bascones Martínez
- Marta Muñoz Corcuera
- Susana Noronha
- Paula Mota
- Cristina Bascones Ilundain
- Julián Campo Trapero
ISSN: 1698-6946
Año de publicación: 2009
Volumen: 14
Número: 12
Páginas: 13
Tipo: Artículo
Otras publicaciones en: Medicina oral, patología oral y cirugía bucal. Ed. inglesa
Resumen
Periodontal diseases are complex bacteria-induced infections characterised by an inflammatory host response to plaque microbiota and their by-products. Most of these microorganisms have virulence factors capable of causing massive tissue destruction both directly, through tissue invasion and the production of harmful substances, or indirectly, by activation of host defense mechanisms, creating an inflammatory infiltrate of potent catabolic activity that can interfere with normal host defense mechanisms. In response to the aggression, host defense mechanisms activate innate and adaptive immune responses. Our aim is to offer a general overview of the main mechanisms involved in the host response to bacterial aggression in periodontitis, such as lipopolysaccharide receptor CD14, complement system, polymorphonuclear neutrophils, antibodies and immunoglobulins.