Ningún efecto favorable de la suplementación de cr (III) en el metabolismo de lípidos en Diabetes tipo 2meta-análisis de ensayos clínicos, simple y doble ciego, controlados con placebo.
- San Mauro Martín, Ismael
- Ruiz León, Ana María
- Garicano Vilar, Elena
- Collado Yurrita, Luis
- Ciudad Cabañas, María José
- de Mateo Silleras, Beatriz
- Redondo del Río, María de Paz
- Camina Martín, María Alicia
ISSN: 2529-850X
Year of publication: 2017
Volume: 2
Issue: 3
Pages: 101-106
Type: Article
More publications in: Journal of Negative and No Positive Results: JONNPR
Abstract
Introduction. Type 2 diabetes mellitus is an important global health issue which prevalence has been increasing in the last years. Many studies have linked chromium supplementation with improvement of type 2 diabetes mellitus.Aim. Perform a meta-analysis of single and double-blind, randomized, placebo controlled trials, where participants diagnosed of type 2 DM or glucose intolerants were supplemented with Cr (III).Methods. Systematic literature search in electronic databases was conducted, using the following search terms: (diabetes) AND (chromium), until July, 2016. Eligible studies were limited to double or single-blind, parallel group, placebo-controlled, randomizedclinical trials, comparing Cr mono or combined supplementation at least for 30 days against placebo, in subjects diagnosed of type 2 DM or with glucose intolerance.Results. Total doses of Cr supplementation and brewer’s yeast ranged from 20 to 1000 μg/day, and duration of supplementation ranged from 30 to 120 days. No statistically significant reduction was found in HDL-C (p=0.63), LDL-C (p=0.53) and TG (p=0.34)compared to placebo; with a weighted average effect size of -0.44 (95% CI: -2.2 to 1.33) mg/dL, -1.43 (95% CI: -5.94 to 3.08) mg/dL and -7.43 (95% CI: -22.67 to 7.82) mg/dL, respectively.Conclusion. Evidence in our study suggests no favourable effects of chromium supplementation on lipid metabolism control in patients with type 2 diabetes.
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