Enfermedad autoinmune sistémica en pacientes con uveítis

  1. J. Carbone
  2. E. Sarmiento
  3. D. Micheloud
  4. M. Rodríguez-Mahou
  5. J.J. Rodríguez-Molina
  6. R. Cobo
  7. E. Fernández-Cruz
Revue:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Année de publication: 2006

Volumen: 81

Número: 4

Pages: 193-198

Type: Article

DOI: 10.4321/S0365-66912006000400004 DIALNET GOOGLE SCHOLAR lock_openAccès ouvert editor

D'autres publications dans: Archivos de la Sociedad Española de Oftalmologia

Résumé

Objective: A descriptive study was conducted on patients with uveitis to determine the frequency of associated autoimmune systemic diseases. Methods: 64 patients with uveitis were studied. The patients were not known to have an underlying autoimmune systemic disease prior to the diagnosis of uveitis. All patients had the following immunological tests performed: serum immunoglobulins, complement components, circulating immune complexes (CIC), antinuclear antibodies (ANA), antineutrophil cytoplasmic antibodies (ANCA), anticardiolipin antibodies (ACA) and major histocompatibilty complex antigens. Results: A relationship with a sub-clinical autoimmune systemic disorder could be presumed in eleven cases (17.2%). This was defined by positive autoantibodies (ANA, ANCA or ACA) in the presence of complement consumption, hyper-gammaglobulinemia or increased CIC without clinical criteria of a defined autoimmune disease. A definite association with systemic autoimmune disease was defined in four patients (6.25%). The observed autoimmune systemic diseases were Sjögren’s syndrome (n=2, 3.13%), anti-phospholipid syndrome associated with lupus-like disease (n=1, 1.6%), and systemic vasculitis (n=1, 1.6%). Lupus-like disease (n=4, 6.25%) was also observed. Conclusion: In a significant proportion of patients with uveitis an autoimmune systemic disorder may be present and should be looked for.

Références bibliographiques

  • Whitcup, SL, Nussenblatt, RB. (1996). Clinical Immunology: Principles and Practice. Mosby. St Louis.
  • Durrani, OM, Meads, CA, Murray, PI. (2004). Uveitis: a potentially blinding disease. Ophthalmologica. 218. 223-236
  • Tay-Kearney, ML, Schwam, BL, Lowder, C, Dunn, JP, Meisler, DM, Vitale, S. (1996). Clinical features and associated systemic diseases of HLA-B27 uveitis. Am J Ophthalmol. 121. 47-56
  • Rothova, A, Buitenhuis, HJ, Meenken, C, Brinkman, CJ, Linssen, A, Alberts, C. (1992). Uveitis and systemic disease. Br J Ophthalmol. 76. 137-141
  • McCluskey, P, Powell, RJ. (2004). The eye in systemic inflammatory diseases. Lancet. 364. 2125-2133
  • Carbone, J, Sanchez-Ramon, S, Cobo-Soriano, R, Seoane, E, Aparicio, MJ, Ruiz-Tiscar, JL. (2001). Antiphospholipid antibodies: a risk factor for occlusive retinal vascular disorders. Comparison with ocular inflammatory diseases. J Rheumatol. 28. 2437-2441
  • Tan, EM, Cohen, AS, Fries, JF, Masi, AT, McShane, DJ, Rothfield, NF. (1982). The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25. 1271-1277
  • Cervera, R, Khamashta, MA, Font, J, Sebastiani, GD, Gil, A, Lavilla, P. (1999). Morbidity and mortality in systemic lupus erythematosus during a 5-year period: A multicenter prospective study of 1,000 patients. Medicine (Baltimore). 78. 167-175
  • Kohli, M, Bennett, RM. (1994). Sacroileitis in systemic lupus erythematosus. J Rheumatol. 21. 170-171
  • Carbone, J, Sarmiento, E, Segovia, P, Rodríguez-Mahou, M, Rodríguez-Molina, JJ, Fernández-Cruz, E. (2002). Anticuerpos antifosfolípidos y evolución a conectivopatía: Estudio de seguimiento de mujeres con abortos de repetición. Med Clin (Barc). 119. 681-685
  • Chipont Benabent, E, Cunningham, ET Jr. (2002). Manejo del paciente con uveítis anterior aguda. Arch Soc Esp Oftalmol. 77. 183-193
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