Edema bilateral del nervio óptico por leucemia linfocítica crónica

  1. F. Sáenz-Francés
  2. C. Calvo-González
  3. J. Reche-Frutos
  4. J. Donate-López
  5. E. Huelga-Zapico
  6. J. García-Sánchez
  7. J. García-Feijoó
Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2007

Volume: 82

Issue: 5

Pages: 303-306

Type: Article

DOI: 10.4321/S0365-66912007000500010 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Archivos de la Sociedad Española de Oftalmologia

Abstract

Case report: We present the case of a 65-year-old man who was seen in the casualty department complaining of bilateral visual loss. His past medical history was unremarkable except for chronic lymphocytic leukaemia diagnosed two years previously: he was no longer receiving treatment for this disorder. His visual acuity was 20/200 in the right eye and 20/63 in the left eye and he had a bilateral papilledema. Computed tomography and magnetic resonance imaging of the brain and orbit were performed and showed an infiltrative mass in the orbit with extension to the ethmoid bone and both optic nerves. Biopsy of the mass was compatible with chronic lymphocytic leukaemia. Discussion: Leukaemic infiltration of the optic nerve and central nervous system is a rare complication of chronic lymphocytic leukaemia, although it is common in the acute forms of this disease. Optic nerve infiltration is the most important ophthalmologic manifestation of leukaemia because it threatens vision and it is treatable.

Bibliographic References

  • Coupland, SE, Foss, H-D, Bechrakis, NE, Hummel, M, Stein, H. (2001). Secondary ocular involvement in systemic «memory» B-cell lymphocytic leukaemia. Ophthalmology. 108. 1289-1295
  • Lin, YC, Wang, AG, Yen, MY, Hsu, WM. (2004). Leukaemic infiltration of the optic nerve as the initial manifestation of leukaemic relapse. Eye. 18. 546-550
  • Sharma, T, Grewal, J, Gupta, S, Murray, PI. (2004). Ophthalmic manifestations of acute leukaemias: the ophthalmologist’s role. Eye. 18. 663-672
  • Shocket, LS, Massaro-Giordano, M, Volpe, NJ, Galetta, SL. (2003). Bilateral optic nerve infiltration in central nervous system leukemia. Am J Ophthalmol. 135. 94-96
  • Mayo, GL, Carter, JE, McKinnon, SJ. (2002). Bilateral optic disk edema and blindness as initial presentation of acute lymphocytic leukemia. Am J Ophthalmol. 134. 141-142