Interferón tópico como tratamiento único en un caso de neoplasia córneo-conjuntival severa
- D Díaz-Valle
- JM Benítez-del-Castillo
- T Díaz-Valle
- Y Poza-Morales
- A Arteaga-Sánchez
ISSN: 0365-6691
Year of publication: 2005
Volume: 80
Issue: 12
Pages: 728-732
Type: Article
More publications in: Archivos de la Sociedad Española de Oftalmologia
Abstract
Case report: A 78-year-old man was referred for evaluation of a limbic lesion in his left eye. This had a gelatinous appearance and an extension of 240º. The lesion was clinically diagnosed to be a conjunctival and corneal intraepithelial neoplasia (CIN). Topical treatment with interferon α2b (INFα2b) four times daily was started and continued until the lesion had completely resolved at 4 months. Discussion: Topical INFα2b alone may be a safe and effective treatment of CIN instead of the other classic alternatives such as surgical excision with cryotherapy, which could induce the development of severe limbic deficiency in cases with extensive disease.
Bibliographic References
- Karp, CL, Moore, JK, Rosa, RH Jr. (2001). Treatment of conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2b. Ophthalmology. 108. 1093-1098
- Schechter, BA, Schrier, A, Nagler, RS, Smith, EF, Velasquez, GE. (2002). Regression of presumed primary conjunctival and corneal intraepithelial neoplasia with topical interferon alpha a-2b. Cornea. 21. 6-11
- Boehm, MD, Huang, AJ. (2004). Treatment of recurrent corneal and conjunctival intraepithelial neoplasia with topical interferon alpha-2b. Ophthalmology. 111. 1755-1761
- Erie, JC, Campbell, RJ, Liesegang, TJ. (1986). Conjunctival and corneal intraepithelial and invasive neoplasia. Ophthalmology. 93. 176-183
- Tabin, G, Levin, S, Snibson, G, Laughnan, M, Taylor, H. (1997). Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology. 104. 485-492