Estudio comparativo de la eficacia hipotensora y de las variaciones en la amplitud de pulso ocular entre las combinaciones fijas dorzolamida/timolol y brinzolamida/timolol

  1. M. Sánchez-Pulgarín
  2. J.M. Martínez-de-la-Casa
  3. J. García-Feijoó
  4. F. Sáenz-Francés
  5. E. Santos-Bueso
  6. R. Herrero-Vanrell
  7. J. García Sánchez
Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2011

Volume: 86

Issue: 5

Pages: 149-153

Type: Article

DOI: 10.1016/J.OFTAL.2011.01.006 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Archivos de la Sociedad Española de Oftalmologia

Abstract

Objective: To determine possible differences in the intraocular pressure (IOP) and ocular pulse amplitude (OPA) lowering capacity of the fixed drug combinations dorzolamide/timolol and brinzolamide/timolol. Methods: In this cross-sectional study, one of the eyes of 25 healthy subjects was randomly assigned to treatment with dorzolamide/timolol and the other eye with brinzolamide/timolol. After instilling the drops, possible adverse effects (e.g., blurred vision, itching) were assessed in each eye. This assessment was repeated 30minutes later. IOP and OPA were determined In each eye by dynamic contour tonometry at baseline and two hours following treatment. Results: Both fixed drug combinations significantly reduced IOP and OPA with no differences detected between treatment groups. Among the adverse effects recorded, itching was significantly greater in the first assessment in the eyes treated with dorzolamide/timolol (P = .011). This difference was no longer apparent in the second assessment. Conclusions: Both fixed combinations were similarly effective in reducing intraocular pressure and ocular pulse amplitude. Adverse effects related to both treatments were mild and well-tolerated, though itching occurred most frequently in the eyes treated with dorzolamide/timolol.

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