Cytotoxic studies and in vitro effects of trans-3,4,4',5-tetramethoxystilbene, a bioactive compound isolated from Lonchocarpus punctatus Kunth

  1. Rocío Borges-Argáez
  2. Mirbella Cáceres-Farfán
  3. Nuria De Pedro
  4. Bastien Cautain
  5. José Pérez Del Palacio
  6. Francisca Vicente
  7. Olga Genilloud
  8. Angeles Melguizo
  9. Caridad Díaz
  10. Fernando Reyes
  11. Noureddine El Aouad
  12. Pablo Sansores-Peraza
Zeitschrift:
Polibotánica

ISSN: 2395-9525,  1405-2768

Datum der Publikation: 2017

Nummer: 43

Seiten: 165-175

Art: Artikel

DOI: 10.18387/POLIBOTANICA.43.7 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Andere Publikationen in: Polibotánica

Zusammenfassung

The bioassay-guided fractionation of Lonchocarpus punctatus inflorescence extracts led to the purification of the trans (1) and cis (2) isomers of 3,5-dimethoxystilbene, trans-3,4,4’,5-tetramethoxystilbene (3), 4,4’,6’-trimethoxychalcone (4) and 5- hydroxy-7,4’-dimethoxyflavone (5) as their main constituents. the structures of the compounds were established by comparing their nuclear magnetic resonance and mass spectrometry data with that from the literature. among these metabolites, trans-3,4,4’,5-tetramethoxystilbene (3) exhibited potent cytotoxic activity against luminal a (CC50= 2.2 μM), HER2 (CC50= 1.1 μM) and basal triple negative (CC50= 1.8 μM) breast cancer cell lines, but no cytotoxic effects were observed against immortalized hepatocyte cell lines (CC50> 50 μM), and medium (CYP3A4, CYP2C9) and low (CYP2D6) inhibitory properties were observed for P450 isoforms.

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Fuente de los datos: Dialnet