Usefulness of compounds with monacolin K in a case of statins intolerance
- Parra-Virto, Alejandro
- Torres do Rego, Ana
- Demelo-Rodríguez, Pablo
- Millán Núñez-Cortés, Jesús
- Álvarez-Sala, Luis A.
ISSN: 0214-9168, 1578-1879
Year of publication: 2018
Volume: 30
Issue: 6
Pages: 268-270
Type: Article
More publications in: Clínica e investigación en arteriosclerosis
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Abstract
Many patients with familial hypercholesterolaemia (FH) or in secondary prevention situations and with statin intolerance do not achieve LDL-C targets, and require treatment with PCSK9 inhibitors (iPCSK9) and ezetimibe. The case is presented on a patient with FH and total intolerance to statins. Treatment with iPCSK9 and ezetimibe failed to achieve her LDL-C target. A compound with red yeast rice derivatives containing 3 mg of monacolin K was added, with good therapeutic compliance, and a very good control of LDL-C. The addition of red yeast rice derivatives containing low doses of monacolin K, together with IPCSK9 in patients with total intolerance to statins, may open a new path to obtain LDL-C targets in patients with high/very high cardiovascular risk.