Papel de la isoforma A del receptor de la insulina y del IGF-1R en el crecimiento de la placa aterosclerótica
- Almudena Gómez Hernández
- Nuria Beneit Redondo
- Liliana Perdomo Loaiza
- Oscar Escribano Illanes
- Sabela Diaz Castroverde Vicario
- Manuel Benito de las Heras
ISSN: 1697-4298, 0034-0618
Year of publication: 2016
Volume: 82
Issue: 2
Pages: 129-142
Type: Article
More publications in: Anales de la Real Academia Nacional de Farmacia
Abstract
In this work, we have obtained new lines of vascular smooth muscle cells (VSMCs) to demonstrate that IRA and IRA/IGF-1R might confer a proliferative and migratory advantage in response to insulin, IGF-2 or TNF-α. These results might be relevant due to in the early stages of atherosclerotic process; we have demonstrated that there is a significant increase of IRA and IGF-1R expression as well as higher formation of hybrid receptors in the aorta from two models of early atherosclerosis. Finally, anti-TNF-α treatment prevented vascular alterations