Antitumorigenic mechanisms of action of peroxisome proliferator-activated gamma (ppargamma) ligands in breast cancer

  1. DORADO PEREZ, JORGE
Dirigée par:
  1. Ana María Pérez Castillo Directeur/trice

Université de défendre: Universidad Autónoma de Madrid

Fecha de defensa: 20 novembre 2009

Jury:
  1. Pilar Santisteban President
  2. I. Ibáñez de Cáceres Secrétaire
  3. Jorge Martín Pérez Rapporteur
  4. Gregorio Angel Santos Montes Rapporteur
  5. Rosario Perona Abellón Rapporteur

Type: Thèses

Teseo: 283675 DIALNET lock_openBiblos-e Archivo editor

Résumé

In this work we have analyzed the antitumorigenic mechanisms of action of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) ligands 15-deoxi-12,14-Prostaglandin J2 , rosiglitazone and pioglitazone on human breast cancer cells. Our data show that treatment with these compounds reduces cell viability, induces inhibition of proliferation and promotes apoptosis in several breast carcinoma cell lines, and attribute for the first time similar effects to members of the thiadiazolidinones (TDZDs) family of compounds.