Papel VEGF en la actividad vascular y en el tejido adiposo peritumoral en el carcinoma colorrectal

Abstract

In Spain, as of December 2014, colorectal carcinoma (CC) was the third most frequent malignancy in men and the second most frequent in women. Generally speaking CC is the malignancy with the highest incidence of 15 %. Knowledge of its physiopathology, early diagnosis, well-executed surgical treatment, and correct staging oriented to adjuvant therapy, will have a role in improving its prognosis. Tumoral angiogenesis follows a complex staged pathway resulting in neo-vessel formation. Vascular endothelium has been considered a complex sensory organ. VEGF is a signalling protein involved in angiogenesis. It has been demonstrated that VEGF stimulates division and migration of endothelial cells; it has also a vasodilator effect and increases vascular permeability. Reversible protein phosphorilation plays an important role in cell activity regulation. Obesity can be defined as excessive weight due to excess adipose tissue. Obesity is a known risk factor for development of CC. Adipose tissue acts both as an energy-storage and an endocrine organ, secreting multifunctional macromolecules with pro-inflammatory activity, which can promote tumor initiation and development...