Una revisión sistemática de las recomendaciones diagnósticas y terapéuticas del panel de expertos en cáncer de origen desconocido

  1. Ferrán Losa Gaspà 1
  2. Carmen Balañá Quintero 2
  3. Gemma Soler González 3
  4. Claudio Ballestín Carcavilla 4
  5. Laia Bernet Vegué 5
  6. Antonio Casado Herráez 6
  7. Anabel Enguita Valls 4
  8. Anna Estival González 2
  9. Alejandra Giménez Ortiz 7
  10. Ana González-Piñeiro 8
  11. Ricardo Hitt 9
  12. Lara Iglesias Docampo 4
  13. Martín Lázaro Quintela 8
  14. Aránzazu Manzano Fernández 6
  15. Eva Musulén Paletl 10
  16. Roberto Pazo Cid 11
  17. Esperanza Torres Sánchez 12
  18. Xavier Matías-Guiu Guía 13
  1. 1 Servicio de Oncología Médica, Hospital Sant Joan Despí-Moisés Broggi. ICO l’Hospitalet, Barcelona, España
  2. 2 Servicio de Oncología Médica, Hospital Germans Trías i Pujol. ICO Badalona, Barcelona, España
  3. 3 Hospital Duran i Reynals
    info
    Hospital Duran i Reynals

    Barcelona, España

    ROR https://ror.org/03qwghy04

    Geographic location of the organization Hospital Duran i Reynals
  4. 4 Hospital Universitario 12 de Octubre
    info
    Hospital Universitario 12 de Octubre

    Madrid, España

    ROR https://ror.org/00qyh5r35

    Geographic location of the organization Hospital Universitario 12 de Octubre
  5. 5 Hospital Xàtiva Lluis Alcanyis
    info
    Hospital Xàtiva Lluis Alcanyis

    Játiva, España

    ROR https://ror.org/03yk4dt83

    Geographic location of the organization Hospital Xàtiva Lluis Alcanyis
  6. 6 Servicio de Oncología Médica, Hospital Universitario San Carlos, Madrid, España
  7. 7 Hospital Universitario La Fe
    info
    Hospital Universitario La Fe

    Valencia, España

    ROR https://ror.org/01ar2v535

    Geographic location of the organization Hospital Universitario La Fe
  8. 8 Hospital Álvaro Cunqueiro
    info
    Hospital Álvaro Cunqueiro

    Vigo, España

    Geographic location of the organization Hospital Álvaro Cunqueiro
  9. 9 Servicio de Oncología Médica, Hospital de Leganés, Madrid, España
  10. 10 Hospital Universitari Germans Trias i Pujol
    info
    Hospital Universitari Germans Trias i Pujol

    Barcelona, España

    ROR https://ror.org/04wxdxa47

    Geographic location of the organization Hospital Universitari Germans Trias i Pujol
  11. 11 Hospital Miguel Servet
    info
    Hospital Miguel Servet

    Zaragoza, España

    ROR https://ror.org/01r13mt55

    Geographic location of the organization Hospital Miguel Servet
  12. 12 Hospital Universitario Virgen de la Victoria
    info
    Hospital Universitario Virgen de la Victoria

    Málaga, España

    ROR https://ror.org/05xxs2z38

    Geographic location of the organization Hospital Universitario Virgen de la Victoria
  13. 13 Hospital Arnau de Vilanova
    info
    Hospital Arnau de Vilanova

    Valencia, España

    ROR https://ror.org/02s7fkk92

    Geographic location of the organization Hospital Arnau de Vilanova
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Journal:
Archivos de medicina

ISSN: 1698-9465

Year of publication: 2019

Volume: 15

Issue: 1

Type: Article

DIALNET GOOGLE SCHOLAR lock_openDialnet editor

More publications in: Archivos de medicina

Sustainable development goals

Abstract

Cancer of Unknown Primary (CUP) is a metastatic cancer with confirmed histology of which the primary origin is unknown after to work up initial evaluation through a pathological clinical study, the analytical and imaging study. The diagnostic process includes the early obtaining of quality biopsy material. It includes its histological and immunohistochemical analysis: a study to determine the tumor line, an analysis of cytokeratins and a large battery of antibodies to confirm the specific origin of each possible tumor type. The development of molecular platforms has allowed improving the diagnosis of CUP, increasing the number of patients who can benefit from treatment with specific therapy, significantly increasing the survival and reducing the toxicity. However, the updated guidelines (NICE, ESMO, NCCN) emphasize that the impact on the clinical benefit of the specific treatment according to the results of the molecular platforms is still controversial.

Data source: Dialnet