Seguimiento longitudinal de la masa ósea en mujeres postmenopáusicas en función de los polimorfismo BSMI y APAI del gen del receptor de la vitamina D (VDR)

Résumé

Osteoporosis is a polygenic disorder that is determined by the effects of several genes, each with relatively modest effects on bone mass. The aim of this study was to determine whether the vitamin D receptor single nucleotide polymorphism BsmI and ApaI are associated with bone mineral density (BMD), BMD figures in osteoporosis and response to the treatment in postmenopausal osteporotic women. A total of 548 postmenopausal osteoporotic women were recruited for the study and 456 were followed for 5-years. Genotype was determined using TaqMan® SNP Genotyping Assays. Lumbar and femoral BMD were determined by dual-energy X-ray absorptiometry (DEXA). Daily calcium and vitamin D intake were determined by a food questionnaire. No associations with BMD (BsmI), BMD figures in osteoporotic women (ApaI) and response to the treatment (BsmI) Osteoporosis is a polygenic disorder that is determined by the effects of several genes, each with relatively modest effects on bone mass. The aim of this study was to determine whether the vitamin D receptor single nucleotide polymorphism BsmI and ApaI are associated with bone mineral density (BMD), BMD figures in osteoporosis and response to the treatment in postmenopausal osteporotic women. A total of 548 postmenopausal osteoporotic women were recruited for the study and 456 were followed for 5-years. Genotype was determined using TaqMan® SNP Genotyping Assays. Lumbar and femoral BMD were determined by dual-energy X-ray absorptiometry (DEXA). Daily calcium and vitamin D intake were determined by a food questionnaire. No associations with BMD (BsmI), BMD figures in osteoporotic women (ApaI) and response to the treatment (BsmI) were found in the studied sample. Our results indicate that the putative role of the BsmI and ApaI in the bone mineral density in postmenopausal osteporotic Spanish women should be questioned.