Epidemiological study of canine mammary tumorsage, breed, size and malignancy

  1. Nieves Pastor
  2. Nuria C. Caballé
  3. Massimo Santella
  4. Luis Javier Ezquerra
  5. Raquel Tarazona
  6. Esther Duran
Revista:
Austral journal of veterinary sciences

ISSN: 0719-8000,  0719-8132

Año de publicación: 2018

Volumen: 50

Número: 3

Páginas: 143-147

Tipo: Artículo

DOI: 10.4067/S0719-81322018000300143 DIALNET GOOGLE SCHOLAR lock_openAcceso abierto editor

Otras publicaciones en: Austral journal of veterinary sciences

Resumen

Abstract: A retrospective study was carried out on 858 female canine patients who were attended at the Surgery Service of the Clinical Veterinary Hospital of the University of Extremadura (Spain), during a period of 5 years (2008-2012). This study aims to determine the incidence of mammary tumors in the canine species of this region together with the analysis of several epidemiological variables (breed, age, and size) and the histopathological variable tumor malignancy. Three groups of patients were considered: (I) general group including all patients (n=858), (II) oncological patients (n=376), and (III) patients with mammary tumors (n=227). Oncology represented the most common pathology for female dogs (n=376, 43.82%), with mammary tumors being the most frequent neoplasms (n=227, 60.37%). Mixed breed dogs were more likely than purebred dogs to suffer from mammary tumors, with these tumors being more frequently malignant. It was also found that large-sized patients show a greater predisposition to malignant mammary tumors. In patients with tumors, age at diagnosis was significantly associated with a higher malignancy rate. The results of the study confirm the importance of oncology in the veterinary clinic in the region. Mammary tumors represent the most frequently diagnosed neoplasia in female dogs. Old age, mixed breed and large size predispose to its development and represent risk factors for malignancy.

Referencias bibliográficas

  • Andrade, F,Figueroa, F,Bersano, P.. (2010). Malignant mammary tumor in female dogs: environmental contaminants. Diagn Pathol. 5. 45
  • Choi, JW,Yoon, HY,Jeong, SW.. (2016). Clinical outcomes of surgically managed spontaneous tumors in 114 client-owned dogs. Immune Network. 16. 116
  • Dobson, JM.. (2013). Breed-predispositions to cancer in pedigree dogs. Vet Sci. 941275
  • Egenvall, A,Bonnett, BN,Ohagen, P,Olson, P,Hedhammar, A. (2005). Incidence of and survival after mammary tumors in a population of over 80,000 insured female dogs in Sweden from 1995 to 2002. Prev Vet Med. 69. 109
  • (2013). Fédération Cynologique Internationale. FCIdog exhibition regulations and supplementary regulations for World and Section Exhibitions. F.C.I..
  • Gilbertson, SR,Kurzman, ID,Zachrau, RE,Hurvitz, AI,Black, MM.. (1983). Canine mammary epithelial neoplasms: biologic implications of morphologic characteristics assessed in 232 dogs. Vet Pathol. 20. 127
  • Gruntzig, K,Graf, R,Hassig, M,Welle, M,Meier, D. (2015). The Swiss Canine Cancer Registry: a retrospective study on the occurrence of tumours in dogs in Switzerland from 1955 to 2008. J Comp Pathol. 152. 161
  • Itoh, T,Uchida, K,Ishikawa, K,Kushima, K,Kushima, E. (2005). Clinicopathological survey of 101 canine mammary gland tumors: differences between small-breed dogs and others. J Vet Med Sci. 67. 345
  • Karayannopoulou, M,Kaldrymidou, E,Dessiris, A.. (1989). Some epidemio logical aspects of canine mammary tumors. Treatment and prognosis. Bulletin of the Hellenic Veterinary Medical Society. 40. 111
  • Lana, SE,Rutteman, GR,Withrow, SJ.. (2007). Small Animal Clinical Oncology. 4. Saunders. Philadelphia, USA.
  • Marconato, L,Leo, C,Girelli, R,Salvi, S,Abramo, F. (2009). Association between waste management and cancer in companion animals. J Vet Intern Med. 23. 564
  • Merlo, DF,Rossi, L,Pellegrino, C,Ceppi, M,Cardellino, U. (2008). Cancer incidence in pet dogs: findings of the Animal Tumor Registry of Genoa, Italy. J Vet Intern Med. 22. 976
  • Misdorp, W.. (2002). Tumors in Domestic Animals. Iowa State Press. Iowa.
  • Moe, L.. (2001). Population-based incidence of mammary tumours in some dog breeds. J Reprod Fertil Suppl. 57. 439
  • Olivera, LO,Oliveira, RT,Loretti, A,Rodrigues, R,Driemeier, D.. (2003). Aspectos epidemiológicos da neoplasia mamária canina. Acta Scientiae Veterinariae. 31. 105
  • Perez Alenza, MD.. (1994). Influencia de la nutrición, alteraciones genéticas y aspectos clínicos en los tumores mamarios caninos. Universidad Complutense de Madrid. España.
  • Perez Alenza, MD,Pena, L,del Castillo, N,Nieto, AI.. (2000). Factors influ encing the incidence and prognosis of canine mammary tumours. J Small Anim Pract. 41. 287
  • Pinho, SS,Carvalho, S,Cabral, J,Reis, CA,Gartner, F.. (2012). Canine tumors: a spontaneous animal model of human carcinogenesis. Transl Res. 159. 165
  • Ranieri, G,Gadaleta, CD,Patruno, R,Zizzo, N,Daidone, MG. (2013). A model of study for human cancer: Spontaneous occurring tumors in dogs. Biological features and translation for new anticancer therapies. Crit Rev Oncol Hematol. 88. 187
  • Rivera, P,von Euler, H.. (2011). Molecular biological aspects on canine and human mammary tumors. Vet Pathol. 48. 132
  • Salas, Y,Márquez, A,Diaz, D,Romero, L.. (2015). Epidemiological Study of Mammary Tumors in Female Dogs Diagnosed during the Period 2002-2012: A Growing Animal Health Problem. PLOS ONE. 10.
  • Sonnenschein, EG,Glickman, LT,Goldschmidt, MH,McKee, LJ.. (1991). Body conformation, diet, and risk of breast cancer in pet dogs: a case-control study. Am J Epidemiol. 133. 694-703
  • Sorenmo, KU,Kristiansen, VM,Cofone, MA,Shofer, FS,Breen, AM. (2009). Canine mammary gland tumours; a histological continuum from benign to malignant; clinical and histopathological evidence. Vet Comp Oncol. 7. 162
  • Thamm, D,Dow, S.. (2009). How companion animals contribute to the fight against cancer in humans. Vet Ital. 45. 111
  • Vascellari, M,Baioni, E,Ru, G,Carminato, A,Mutinelli, F.. (2009). Animal tumour registry of two provinces in northern Italy: incidence of spontaneous tumours in dogs and cats. BMC Vet Res. 5. 39
  • Vascellari, M,Capello, K,Carminato, A,Zanardello, C,Baioni, E. (2016). Incidence of mammary tumors in the canine population living in the Veneto region (Northeastern Italy): Risk factors and similarities to human breast. Prev Vet Med. 126. 183
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